A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
NCT06842498
This study is recruiting at 23 US sites in 14 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to evaluate the safety, efficacy, tolerability, and pharmacokinetics (PK) of FG-3246, a cluster of differentiation 46 (CD46) targeting antibody-drug conjugate (ADC), in the treatment of participants with mCRPC who have progressed following treatment with one prior second-generation androgen receptor signaling inhibitor (ARSI) in any setting and no prior taxane therapy in the mCRPC setting.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Castration-Resistant Prostate Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- Kyntra Bio
- Last updated on ClinicalTrials.gov
- August 17, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 3
- Western Regional Medical Center - City of Hope Phoenix Goodyear · Goodyear, AZ
- HonorHealth Research Institute · Scottsdale, AZ
- The University of Arizona Cancer Center - North Campus · Tucson, AZ
California · 3
- UCLA Clark Urology Center · Los Angeles, CA
- VA Greater Los Angeles Healthcare System · Los Angeles, CA
- University of California San Francisco · San Francisco, CA
Connecticut · 1
- New Haven Hospital - Yale Cancer Center · New Haven, CT
Florida · 3
- Bioresearch Partner - Aventura · Aventura, FL
- Bioresearch Partner - Hialeah · Hialeah, FL
- Biogenix Molecular, LLC · Miami, FL
Georgia · 1
- Winship Cancer Institute, Emory University · Atlanta, GA
Louisiana · 1
- East Jefferson General Hospital Metairie · New Orleans, LA
New Mexico · 1
- New Mexico Oncology Hematology Consultants, Ltd. · Albuquerque, NM
North Carolina · 1
- Duke University Medical Center - Duke Cancer Center · Durham, NC
Ohio · 1
- University Hospitals Cleveland Medical Center · Cleveland, OH
South Carolina · 1
- Carolina Urologic Research Center · Myrtle Beach, SC
Tennessee · 1
- Henry-Joyce Cancer Clinic · Nashville, TN
Texas · 2
- University of Texas Southwestern Medical Center · Dallas, TX
- Oncology Consultants · Houston, TX
Virginia · 1
- University of Virginia Comprehensive Cancer Center · Charlottesville, VA
Washington · 3
- Fred Hutchinson Cancer Center · Seattle, WA
- University of Washington Medical Center · Seattle, WA
- Northwest Medical Specialties, PLLC - Tacoma · Tacoma, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.