A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
NCT06680830
This study is recruiting at 44 US sites in 29 states, according to its ClinicalTrials.gov record last updated .
Summary
The goal of this Phase 2 clinical trial is to investigate the efficacy and safety of NEU-411 in men and women aged 40-80 years with early Parkinson's Disease (PD) who have predicted elevations in the activity of the "leucine-rich repeat kinase 2" ("LRRK2" for short) pathway based on their genetic profile. A DNA test will be used to identify the "LRRK2-driven" population with predicted elevation in the LRRK2 pathway.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Parkinson Disease
- Parkinson
- Idiopathic Parkinson Disease
- Early Parkinson Disease (Early PD)
- Parkinson Disease, Idiopathic
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 40 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Neuron23 Inc.
- Last updated on ClinicalTrials.gov
- October 2, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Banner Sun Health Research Institute · Sun City, AZ
Arkansas · 1
- University of Arkansas · Little Rock, AR
California · 5
- Neuro-Pain Medical Center · Fresno, CA
- University of California, Irvine · Irvine, CA
- University of California, Los Angeles · Los Angeles, CA
- Parkinson's Research Centers of America - Palo Alto · Palo Alto, CA
- Sutter Neuroscience Institute · Sacramento, CA
Colorado · 1
- University of Colorado - Anschutz Medical Campus · Aurora, CO
Florida · 4
- Parkinson's Disease and Movement Disorders Center of Boca Raton · Boca Raton, FL
- University of Florida · Gainesville, FL
- Neurology One · Orlando, FL
- USF Parkinson's & Movement Disorders Clinic · Tampa, FL
Georgia · 2
- Emory University · Atlanta, GA
- Augusta University · Augusta, GA
Illinois · 1
- Northwestern Medical Group, Department of Neurology · Chicago, IL
Kansas · 1
- University of Kansas Medical Center · Kansas City, KS
Kentucky · 1
- University of Kentucky · Lexington, KY
Louisiana · 1
- Ochsner Clinic Foundation · New Orleans, LA
Maryland · 1
- University of Maryland · Baltimore, MD
Massachusetts · 1
- Beth Israel Deaconess Medical Center · Boston, MA
Michigan · 1
- Quest Research Institute · Farmington Hills, MI
Minnesota · 1
- Struthers Parkinson Center · Golden Valley, MN
Nevada · 1
- Cleveland Clinic · Las Vegas, NV
New Mexico · 1
- University of New Mexico · Albuquerque, NM
New York · 4
- Northwell Health · Manhasset, NY
- Columbia University · New York, NY
- Icahn School of Medicine at Mount Sinai/Mount Sinai West · New York, NY
- University of Rochester · Rochester, NY
North Carolina · 1
- University of North Carolina - Chapel Hill · Chapel Hill, NC
Ohio · 1
- The Ohio State University · Columbus, OH
Oklahoma · 1
- The Movement Disorder Clinic of Oklahoma · Tulsa, OK
Oregon · 1
- Oregon Health & Science University (OHSU) · Portland, OR
Pennsylvania · 1
- Thomas Jefferson University Hospital · Philadelphia, PA
South Carolina · 1
- Medical University of South Carolina · Charleston, SC
Tennessee · 1
- Vanderbilt University · Nashville, TN
Texas · 4
- Neurology Consultants of Dallas PA · Dallas, TX
- Baylor College of Medicine · Houston, TX
- The University of Texas Health Science Center at Houston · Houston, TX
- Central Texas Neurology Consultants · Round Rock, TX
Utah · 1
- University of Utah Movement Division · Salt Lake City, UT
Virginia · 1
- University of Virginia · Charlottesville, VA
Washington · 2
- EvergreenHealth · Kirkland, WA
- Inland Northwest Research · Spokane, WA
Wisconsin · 1
- Medical College of Wisconsin · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.