The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

Summary

This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tobacco-flavored, or menthol-flavored e-cigarettes and be instructed to switch (versus smoking cigarettes) over a 6-week period. Flavor-associated subjective reward and the reinforcing value of flavored e-cigarettes relative to combustible cigarettes will be assessed as mechanisms.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Smoking
• Tobacco Use
• Cigarette Smoking
• E-Cig Use

Eligibility basics and study details

Study type

Interventional

Phase

Not applicable

Ages

21 years and older

Sex

All

Healthy volunteers

Accepted

Sponsor

Abramson Cancer Center at Penn Medicine

Last updated on ClinicalTrials.gov

February 19, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites