Preventing Injured Knees From osteoArthritis: Severity Outcomes
NCT06096259
This study is recruiting at 9 US sites in 8 states, according to its ClinicalTrials.gov record last updated .
Summary
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction. This research study will compare metformin to placebo. The placebo tablet looks exactly like metformin, but contains no metformin. Placebos are used in research studies to see if the results are due to the study drug or due to other reasons. Metformin is approved by the U.S. Food and Drug Administration (FDA) to treat type II diabetes.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Osteoarthritis, Knee
- Post-traumatic Osteoarthritis
- ACL Tear
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Brigham and Women's Hospital
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Georgia · 1
- Emory University · Atlanta, GA
Iowa · 1
- University of Iowa Hospitals and Clinics · Iowa City, IA
Kentucky · 1
- University of Kentucky · Lexington, KY
Massachusetts · 1
- Brigham and Women's Hospital · Boston, MA
Nebraska · 1
- University of Nebraska Medical Center · Omaha, NE
New York · 1
- Hospital for Special Surgery · New York, NY
North Carolina · 1
- The University of North Carolina at Chapel Hill · Chapel Hill, NC
Ohio · 2
- Cleveland Clinic · Cleveland, OH
- The Ohio State University · Columbus, OH
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.