A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer
NCT06095089
This study is recruiting at 12 US sites in 11 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of Parts 1, 2A, and 2B of the study is to determine the recommended regimen for Phase 2 (RP2Rs) of combination of JNJ-87189401 with JNJ-78278343 and the purpose of Part 2C of this study is to determine how safe the RP2R(s) of the combination of JNJ-87189401 and JNJ-78278343 is, with or without apalutamide. Part 3 of this study evaluates the safety of the triplet combination of JNJ-87189401 and JNJ-78278343 with standard of care (SOC) lutetium Lu-177 vipivotide tetraxetan.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Prostatic Neoplasms
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- Janssen Research & Development, LLC
- Last updated on ClinicalTrials.gov
- September 28, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Colorado · 1
- University of Colorado Anschutz Medical Campus · Aurora, CO
Georgia · 1
- Emory University Winship Cancer Institute · Atlanta, GA
Minnesota · 1
- University Of Minnesota · Minneapolis, MN
New Jersey · 1
- START New Jersey · East Brunswick, NJ
New York · 1
- Herbert Irving Comprehensive Cancer Center Columbia University Medical Center · New York, NY
North Carolina · 1
- Atrium Health Levine Cancer Institute · Charlotte, NC
Oregon · 1
- Oregon Health And Science University · Portland, OR
Pennsylvania · 1
- Sidney Kimmel Cancer Center - Jefferson Health · Philadelphia, PA
Tennessee · 1
- Tennessee Oncology · Nashville, TN
Texas · 2
- MD Anderson Cancer Center · Houston, TX
- South Texas Accelerated Research Therapeutics, LLC (START) · San Antonio, TX
Washington · 1
- Swedish Medical Center · Seattle, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.