Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
NCT06034405
This study is recruiting at 5 US sites in 4 states, according to its ClinicalTrials.gov record last updated .
Summary
Primary objective: To identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modifying therapies are most effective. The specific aims of this epidemiologic investigation include: To identify subjects with previous lumbar spinal stenosis (LSS) Surgery who have evidence of transthyretin (TTR) amyloid deposits in spinal specimens and could be at risk for ATTR cardiac amyloidosis. To evaluate for ATTR-CA among those with localized TTR in the spinal tissue.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Lumbar Spinal Stenosis
- Cardiac Amyloidosis
- ATTR Amyloidosis Wild Type
- ATTR Gene Mutation
- ATTRV122I Amyloidosis
- Cardiomyopathy, Hypertrophic
Eligibility basics and study details
- Study type
- Observational
- Phase
- Not applicable
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Sponsor
- Columbia University
- Last updated on ClinicalTrials.gov
- June 4, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 1
- Cedars-Sinai Medical Center · Beverly Hills, CA
Massachusetts · 2
- Boston Medical Center · Boston, MA
- Tufts Medical Center · Boston, MA
New York · 1
- Columbia University Irving Medical Center · New York, NY
Ohio · 1
- Cleveland Clinic · Cleveland, OH
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.