Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
NCT05962229
This study is recruiting at 1 US site in 1 state, according to its ClinicalTrials.gov record last updated .
Summary
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Nicotine Dependence
- Nicotine Vaping
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1
- Ages
- 21 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Sponsor
- University of California, San Francisco
- Last updated on ClinicalTrials.gov
- May 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 1
- Zuckerberg San Francisco General Hospital (ZSFG) · San Francisco, CA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.