Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

Summary

The investigators will study whether the drug tadalafil improves shortness of breath in 126 Veterans with Chronic Obstructive Pulmonary Disease (COPD) and high blood pressure in the lungs. The investigators will also assess whether tadalafil improves quality of life, home daily physical activity, exercise endurance, the frequency of acute flares of COPD, blood pressure in the lungs, and lung function. Veterans who enroll in the trial will be allocated by chance to either active tadalafil or an inactive identical capsule (placebo).

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Chronic Obstructive Pulmonary Disease
• Pulmonary Hypertension
• Dyspnea

Eligibility basics and study details

Study type

Interventional

Phase

Phase 2

Ages

35 to 89 years

Sex

All

Healthy volunteers

Not accepted

Sponsor

VA Office of Research and Development

Last updated on ClinicalTrials.gov

May 15, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites