Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells
NCT05691465
This study is recruiting at 10 US sites in 8 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial studies how well lutetium Lu 177 dotatate works in treating patients with prostate cancer with neuroendocrine differentiation that has spread to other places in the body (metastatic). Neuroendocrine differentiation refers to cells that have traits of both hormone-producing endocrine cells and nerve cells. These cells release hormones into the blood in response to a signal from the nervous system. Hormones are biological substances that circulate through the bloodstream to control the activity of other organs or cells in the body.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation
- Metastatic Prostate Neuroendocrine Carcinoma
- Metastatic Prostate Small Cell Neuroendocrine Carcinoma
- Stage IVB Prostate Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 2
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
Illinois · 1
- Northwestern University · Chicago, IL
Kentucky · 1
- University of Kentucky/Markey Cancer Center · Lexington, KY
Maryland · 1
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
North Carolina · 1
- Wake Forest University Health Sciences · Winston-Salem, NC
Ohio · 1
- Ohio State University Comprehensive Cancer Center · Columbus, OH
Texas · 1
- UT MD Anderson Cancer Center · Houston, TX
Wisconsin · 2
- University of Wisconsin Carbone Cancer Center - Eastpark Medical Center · Madison, WI
- University of Wisconsin Carbone Cancer Center - University Hospital · Madison, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.