Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
NCT05277558
This study is recruiting at 2 US sites in 2 states, according to its ClinicalTrials.gov record last updated .
Summary
Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, inflammation, β-cell dysfunction and dysglycemia) that pose a risk for the brain. Investigators will determine which of these factors are most associated with differences in brain structure and function among groups, over time, and how these effects differ from normal neurodevelopment.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Type2 Diabetes
- Type 2 Diabetes Mellitus in Obese
- Dysglycemia
- Microvascular Complications
- Brain Structure
- Obesity, Childhood
- Diabetes in Adolescence
- Inflammation
- Insulin Resistance
- Overweight, Childhood
- Cognitive Decline
Eligibility basics and study details
- Study type
- Observational
- Phase
- Not applicable
- Ages
- 12 to 17 years
- Sex
- All
- Healthy volunteers
- Accepted
- Sponsor
- Washington University School of Medicine
- Last updated on ClinicalTrials.gov
- December 18, 2025
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Missouri · 1
- Washington University School of Medicine · St Louis, MO
Pennsylvania · 1
- UPMC Children's Hospital of Pittsburgh · Pittsburgh, PA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.