Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer
NCT04787744
This study is recruiting at 16 US sites in 14 states, according to its ClinicalTrials.gov record last updated .
Summary
This is a prospective, open-label, multi-center seamless phase II to phase III randomized clinical trial designed to compare SST with or without PET-directed local therapy in improving the castration-resistant prostate cancer-free survival (CRPC-free survival) for Veterans with oligometastatic prostate cancer. Oligometastasis will be defined as 1-10 sites of metastatic disease based on the clinical determination of the LSI which incorporates all imaging, clinical, and pathologic data available.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Prostate Cancer
- Oligometastasis
- Oligorecurrence
- Recurrent Prostate Cancer
- Metastatic Prostate Cancer
- De Novo Prostate Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2/3
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- VA Office of Research and Development
- Last updated on ClinicalTrials.gov
- April 8, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 2
- VA Long Beach Healthcare System, Long Beach, CA · Long Beach, CA
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA · West Los Angeles, CA
District of Columbia · 1
- Washington DC VA Medical Center, Washington, DC · Washington D.C., DC
Florida · 1
- Bay Pines VA Healthcare System, Pay Pines, FL · Bay Pines, FL
Illinois · 1
- Edward Hines Jr. VA Hospital, Hines, IL · Hines, IL
Indiana · 1
- Richard L. Roudebush VA Medical Center, Indianapolis, IN · Indianapolis, IN
Maryland · 1
- Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD · Baltimore, MD
Massachusetts · 1
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA · Boston, MA
Michigan · 1
- VA Ann Arbor Healthcare System, Ann Arbor, MI · Ann Arbor, MI
North Carolina · 1
- Durham VA Medical Center, Durham, NC · Durham, NC
Ohio · 1
- Louis Stokes VA Medical Center, Cleveland, OH · Cleveland, OH
Pennsylvania · 1
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA · Philadelphia, PA
Texas · 1
- Michael E. DeBakey VA Medical Center, Houston, TX · Houston, TX
Virginia · 1
- Hunter Holmes McGuire VA Medical Center, Richmond, VA · Richmond, VA
Wisconsin · 2
- William S. Middleton Memorial Veterans Hospital, Madison, WI · Madison, WI
- Clement J. Zablocki VA Medical Center, Milwaukee, WI · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.