Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Summary

This trial compares cryoablation combined with stereotactic body radiation therapy to stereotactic body radiation therapy alone to see how well they work in treating patients with pain from cancer that has spread to the bones (bone metastases). Bone is a common site of metastasis in advanced cancer, and bone metastases often result in debilitating cancer-related pain. The current standard of care to treat painful bone metastases is radiation therapy alone. However, many patients do not get adequate pain relief from radiation therapy alone.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Castration-Resistant Prostate Carcinoma
• Metastatic Colorectal Carcinoma
• Metastatic Malignant Neoplasm in the Bone
• Metastatic Malignant Solid Neoplasm
• Metastatic Melanoma
• Metastatic Prostate Carcinoma
• Metastatic Renal Cell Carcinoma
• Metastatic Sarcoma
• Metastatic Thyroid Gland Carcinoma
• Metastatic Urothelial Carcinoma
• Stage IV Colorectal Cancer AJCC v8
• Stage IV Prostate Cancer AJCC v8
• Stage IV Renal Cell Cancer AJCC v8
• Stage IVA Colorectal Cancer AJCC v8
• Stage IVA Prostate Cancer AJCC v8
• Stage IVB Colorectal Cancer AJCC v8
• Stage IVB Prostate Cancer AJCC v8
• Stage IVC Colorectal Cancer AJCC v8

Eligibility basics and study details

Study type

Interventional

Phase

Not applicable

Ages

18 years and older

Sex

All

Healthy volunteers

Not accepted

Sponsor

M.D. Anderson Cancer Center

Last updated on ClinicalTrials.gov

April 15, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites