RA-PRO PRAGMATIC TRIAL
NCT04692493
This study is recruiting at 48 US sites in 18 states, according to its ClinicalTrials.gov record last updated .
Summary
The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab, abatacept, tocilizumab, or sarilumab) or a targeted synthetic DMARD arm (tsDMARD; choose among existing medications, currently, tofacitinib, baricitinib, upadacitinib) in patients with active RA despite the use of a TNFi-biologic. In practice, most patients receive another TNFi-biologic, i.e., a second TNFi-biologic first.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Rheumatoid Arthritis
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- University of Alabama at Birmingham
- Last updated on ClinicalTrials.gov
- September 24, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 3
- East Alabama Arthritis Center PC · Auburn, AL
- Bendcare, LLC · Birmingham, AL
- University of Alabama at Birmingham · Birmingham, AL
Arizona · 2
- SunValley Arthritis Center, Ltd · Peoria, AZ
- University of Arizona · Tucson, AZ
California · 5
- Pacific Arthritis Care Center · Los Angeles, CA
- University of California, Los Angeles · Los Angeles, CA
- Arthritis Medical Center · Nipomo, CA
- Turlock Arthritis & Osteoporosis Center, · Turlock, CA
- Center for Rheumatology Research · Woodland Hills, CA
Florida · 9
- George Munoz MD, PC · Aventura, FL
- American Arthritis and Rheumatology Associates LLC · Clearwater, FL
- CZ Rheumatology · Coral Springs, FL
- American Arthritis and Rheumatology Associates LLC · Fort Lauderdale, FL
- Mayo Clinic Jacksonville · Jacksonville, FL
- Palm Beach Rheumatology and Wellness · Jupiter, FL
- Arthritis & Rheumatology Center of South Florida · Margate, FL
- Life Medical Research Group · Miami Gardens, FL
- Southwest Florida Rheumatology · Riverview, FL
Georgia · 1
- Southeast Georgia Physician Associates-Rheumatology · Brunswick, GA
Indiana · 1
- Indiana University Health · Carmel, IN
Maryland · 1
- Johns Hopkins University · Baltimore, MD
Massachusetts · 2
- Tufts University · Boston, MA
- University of Massachusetts Chan Medical School · Worcester, MA
Michigan · 1
- American Arthritis and Rheumatology Associates -Mi PLLC · Okemos, MI
Minnesota · 2
- Saint Paul Rheumatology, P.A. · Eagan, MN
- Mayo Clinic Rochester · Rochester, MN
New Mexico · 2
- Dr. Jayashree Sinha · Clovis, NM
- Inspire Santa Fe Medical Group · Santa Fe, NM
New York · 2
- Hospital for Special Surgery · New York, NY
- New York University · New York, NY
Ohio · 4
- The MetroHealth System · Cleveland, OH
- University Hospital Cleveland Medical Ctr · Cleveland, OH
- Arthritis and Rheumatology of Southwest Ohio · Liberty Township, OH
- Southern Ohio Rheumatology · Wheelersburg, OH
Oregon · 1
- Oregon Health and Science University · Portland, OR
Pennsylvania · 4
- Altoona Center for Clinical Research · Duncansville, PA
- Rheumatology and Arthritis Care Center · Exton, PA
- Allegheny Health Network · Pittsburgh, PA
- PA Regional Center for Arthritis and Osteoporosis Research · Wyomissing, PA
Tennessee · 2
- Cumberland Rhematology · Crossville, TN
- Vanderbilt University · Nashville, TN
Texas · 5
- Heritage Rheumatology and Arthritis Care · Colleyville, TX
- Southwest Medical Center · Dallas, TX
- Texas Arthritis Center, PA · El Paso, TX
- American Arthritis and Rheumatology Associates-Tx PLLC · Harlingen, TX
- Baylor University · Houston, TX
Virginia · 1
- Northern Virginia Center for Arthritis-Reston · Reston, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.