Oxytocin for Weight Loss in Adolescents

Summary

This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in youths with obesity, ages 10-18 years old. Subjects will be randomized to receive intranasal oxytocin or placebo (1 spray per nostril, 4 times per day) for 12 weeks. Study visits include screening to determine eligibility, 2-part main study visits at baseline, week 8, and week 12, and safety check-in visits at weeks 1, and 4; phone calls at weeks 2, 6, and 10, with a safety follow-up visit 6 weeks after the last dose of study drug.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Obesity, Adolescent
• Oxytocin

Eligibility basics and study details

Study type

Interventional

Phase

Phase 2

Ages

10 to 18 years

Sex

All

Healthy volunteers

Not accepted

Sponsor

Massachusetts General Hospital

Last updated on ClinicalTrials.gov

June 26, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites