Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
NCT04262206
This study is recruiting at 89 US sites in 32 states, according to its ClinicalTrials.gov record last updated .
Summary
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Cognitive Impairment, Mild
- Dementia
- Cardiovascular Diseases
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 4
- Ages
- 75 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Sponsor
- Duke University
- Last updated on ClinicalTrials.gov
- September 1, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 2
- Birmingham VA · Birmingham, AL
- University of Alabama at Birmingham · Birmingham, AL
Arizona · 1
- Southern Arizona VA Health Care System - Tucson · Tucson, AZ
Arkansas · 2
- Little Rock VA Medical Center · Little Rock, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 5
- Fresno VA Medical Center · Fresno, CA
- Long Beach VA Medical Center · Long Beach, CA
- VA Greater Los Angeles · Los Angeles, CA
- VA Northern California Health Care System · Mather, CA
- VA San Diego Medical Center · San Diego, CA
Connecticut · 2
- Yale University · New Haven, CT
- VA Connecticut Healthcare System · West Haven, CT
Florida · 5
- Bay Pines VA · Bay Pines, FL
- Gainesville VA Medical Center · Gainesville, FL
- University of Florida · Gainesville, FL
- University of Florida · Jacksonville, FL
- University of Miami · Miami, FL
Georgia · 2
- Atlanta VA Medical Center · Atlanta, GA
- Emory University · Atlanta, GA
Illinois · 7
- Chicago VA Medical Center/Jesse Brown VA · Chicago, IL
- Northwestern University · Chicago, IL
- Rush University Medical Center · Chicago, IL
- University of Chicago · Chicago, IL
- University of Illinois at Chicago · Chicago, IL
- Hines VA Medical Center · Hines, IL
- North Chicago VA Medical Center · North Chicago, IL
Indiana · 1
- Indianapolis VA Medical Center · Indianapolis, IN
Iowa · 1
- University of Iowa Healthcare · Iowa City, IA
Kansas · 2
- University of Kansas Medical Center · Kansas City, KS
- VA Eastern Kansas Healthcare System · Topeka, KS
Kentucky · 1
- Louisville VA Medical Center · Louisville, KY
Louisiana · 1
- Ochsner Clinic Foundation · New Orleans, LA
Maine · 1
- Maine VA Health Care System · Togus, ME
Maryland · 1
- Johns Hopkins University · Baltimore, MD
Massachusetts · 1
- VA Boston Healthcare System · Boston, MA
Michigan · 2
- University of Michigan · Ann Arbor, MI
- VA Ann Arbor Healthcare System · Ann Arbor, MI
Minnesota · 2
- Essentia Health · Duluth, MN
- Mayo Clinic · Rochester, MN
Mississippi · 2
- University of Mississippi Medical Center · Jackson, MS
- VA Medical Center Jackson · Jackson, MS
Missouri · 4
- University of Missouri Health System · Columbia, MO
- Kansas City VA Medical Center · Kansas City, MO
- St. Louis VA Medical Center · St Louis, MO
- Washington University in St. Louis · St Louis, MO
Nebraska · 2
- Omaha VA Medical Center · Omaha, NE
- University of Nebraska Medical Center · Omaha, NE
New York · 5
- Northwell Health · Manhasset, NY
- VA New York Harbor Healthcare System · New York, NY
- Weill Cornell Medical College · New York, NY
- Albert Einstein College of Medicine · The Bronx, NY
- Bronx VA Medical Center · The Bronx, NY
North Carolina · 8
- Asheville VA-Charles George VA Medical Center · Asheville, NC
- University of North Carolina · Chapel Hill, NC
- Atrium Health · Charlotte, NC
- Duke University · Durham, NC
- PREVENTABLE Tele-Site · Durham, NC
- Duke University - Kannapolis · Kannapolis, NC
- Wake Forest Baptist Hospital-Cardiology · Winston-Salem, NC
- Wake Forest Hospital - Geriatrics · Winston-Salem, NC
Ohio · 4
- Cincinnati VA Medical Center · Cincinnati, OH
- Case Western Reserve University · Cleveland, OH
- Ohio State University · Columbus, OH
- Dayton VA Medical Center · Dayton, OH
Pennsylvania · 1
- University of Pittsburgh Medical Center · Pittsburgh, PA
Rhode Island · 1
- Providence VA Medical Center · Providence, RI
South Carolina · 3
- Charleston VA Medical Center · Charleston, SC
- Medical University of South Carolina · Charleston, SC
- Columbia VA Health Care System/Dorn VA Medical Center · Columbia, SC
Tennessee · 3
- Meharry Medical College · Nashville, TN
- Nashville VA Medical Center · Nashville, TN
- Vanderbilt University Medical Center · Nashville, TN
Texas · 7
- Baylor Scott and White Medical Center · Dallas, TX
- Dallas VA Medical Center · Dallas, TX
- University of Texas Southwestern Medical Center Dallas · Dallas, TX
- Doctors Hospital at Renaissance · Edinburg, TX
- University of Texas at Houston · Houston, TX
- San Antonio VA Medical Center · San Antonio, TX
- University of Texas Health Science Center at San Antonio · San Antonio, TX
Utah · 2
- Intermountain · Murray, UT
- VA Salt Lake City Healthcare System · Salt Lake City, UT
Virginia · 1
- McGuire VA Medical Center · Richmond, VA
Wisconsin · 7
- Mayo Clinic Health Systems - NW Wisconsin · Eau Claire, WI
- Mayo Clinic Health System SW Wisconsin · La Crosse, WI
- Madison VA Medical Center · Madison, WI
- University of Wisconsin at Madison · Madison, WI
- Marshfield Clinic · Marshfield, WI
- Medical College of Wisconsin · Milwaukee, WI
- Milwaukee VA Medical Center · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.