Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

Summary

Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension). Exposure to heat, such as in hot environments, often worsens their orthostatic hypotension. The causes of this are not fully understood. The purpose of this study is to evaluate whether applying local heat over the abdomen of patients with autonomic failure and supine hypertension during the night would decrease their nocturnal high blood pressure while lying down.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Hypertension
• Pure Autonomic Failure
• Multiple System Atrophy
• Autonomic Failure

Eligibility basics and study details

Study type

Interventional

Phase

Not applicable

Ages

18 to 80 years

Sex

All

Healthy volunteers

Not accepted

Sponsor

Vanderbilt University Medical Center

Last updated on ClinicalTrials.gov

January 16, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites