Natural History Study of Synucleinopathies

Summary

Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein α-synuclein in the nervous system. Onset is usually in late adulthood at age 50 or older. Usually, synucleinopathies present clinically with slowness of movement, coordination difficulties or mild cognitive impairment. Development of these features indicates that abnormal alpha-synuclein deposits have destroyed key areas of the brain involved in the control of movement or cognition.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Patients With Synucleinopathies
• Neurogenic Orthostatic Hypotension
• Pure Autonomic Failure
• REM Sleep Behavior Disorder
• Parkinson Disease
• Dementia With Lewy Bodies
• Multiple System Atrophy
• Shy-Drager Disease

Eligibility basics and study details

Study type

Observational

Phase

Not applicable

Ages

18 years and older

Sex

All

Healthy volunteers

Not accepted

Sponsor

NYU Langone Health

Last updated on ClinicalTrials.gov

June 10, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites