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Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias

NCT01060371

This study is recruiting at 14 US sites in 11 states, according to its ClinicalTrials.gov record last updated .

Summary

Spinocerebellar ataxias (SCA) are genetic neurological diseases that cause imbalance, poor coordination, and speech difficulties. There are different kinds of SCAs and this study will focus on types 1, 2, 3, 6, 7, 8, 10, 27B, and RFC1-ataxia (SCA 1, SCA 2, SCA 3, also known as Machado-Joseph disease, SCA 6, SCA 7, SCA 8, SCA 10, SCA27B, and RFC1-ataxia, also known as CANVAS). The diseases are rare, slowly progressive, cause increasingly severe neurological difficulties, and are variable across and within genotypes.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

  • Spinocerebellar Ataxia Type 1
  • Spinocerebellar Ataxia Type 2
  • Spinocerebellar Ataxia Type 3
  • Spinocerebellar Ataxia Type 6
  • Spinocerebellar Ataxia Type 7
  • Spinocerebellar Ataxia Type 8
  • Spinocerebellar Ataxia Type 10
  • RFC1 Gene Mutation
  • Spinocerebellar Ataxia Type 27b
  • Healthy Participants

Eligibility basics and study details

Study type
Observational
Phase
Not applicable
Ages
6 years and older
Sex
All
Healthy volunteers
Accepted
Sponsor
Lauren Moore
Last updated on ClinicalTrials.gov
August 3, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites

California · 2

  • University of California Los Angeles · Los Angeles, CA
  • University of California San Francisco · San Francisco, CA

Florida · 2

  • University of Florida · Gainesville, FL
  • University of South Florida · Tampa, FL

Georgia · 1

  • Emory University · Atlanta, GA

Illinois · 1

  • Nortwestern University · Chicago, IL

Maryland · 1

  • John Hopkins University · Baltimore, MD

Massachusetts · 1

  • Harvard University · Boston, MA

Michigan · 1

  • University of Michigan · Ann Arbor, MI

New York · 1

  • Columbia University · New York, NY

Pennsylvania · 1

  • University of Pennsylvania · Philadelphia, PA

Texas · 2

  • University of Texas Southwestern Medical Center · Dallas, TX
  • Houston Methodist · Houston, TX

Washington · 1

  • University of Washington · Seattle, WA

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.