Confirmatory Trial of Gamma Neurofeedback to Improve Working Memory in Schizophrenia

Summary

This study is a confirmatory, double-blind, placebo-controlled randomized clinical trial (RCT) testing whether gamma EEG neurofeedback (EEG-NFB) improves working memory in adults with schizophrenia or schizoaffective disorder. Participants are randomly assigned to receive either active gamma EEG-NFB (real-time feedback of frontal gamma brain activity) or sham EEG-NFB (false pre-recorded feedback), twice weekly for 12 weeks. Working memory (N-back task), brain gamma coherence, and everyday community functioning are assessed at baseline, mid-treatment, end of treatment, and follow-up.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• SCHIZOPHRENIA 1 (Disorder)
• Schizoaffecitve Disorder

Eligibility basics and study details

Study type

Interventional

Phase

Phase 2

Ages

18 to 55 years

Sex

All

Healthy volunteers

Not accepted

Sponsor

University of California, San Diego

Last updated on ClinicalTrials.gov

November 10, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites