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Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer

NCT07476287

This study is recruiting at 23 US sites in 4 states, according to its ClinicalTrials.gov record last updated .

Summary

This study is being done to learn more about a new medicine called PF-08634404. The study team wants to understand how well PF-08634404 works when given alone or with chemotherapy . Chemotherapy is a type of cancer treatment that uses medicines to destroy cancer cells or stop them from growing. The study is for adults with Transformed Small Cell Lung Cancer (T-SCLC ). T SCLC is a rare lung cancer that happens when one type of lung cancer changes into a more aggressive type after treatment stops working.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

  • Small Cell Lung Cancer
  • Small Cell Lung Cancer ( SCLC )
  • Transformed Small Cell Lung Cancer
  • Lung Neoplasms
  • Carcinoma, Small Cell Lung
  • Small Cell Cancer Of The Lung

Eligibility basics and study details

Study type
Interventional
Phase
Phase 2
Ages
18 years and older
Sex
All
Healthy volunteers
Not accepted
Sponsor
Pfizer
Last updated on ClinicalTrials.gov
October 9, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites

California · 12

  • City of Hope National Medical Center · Duarte, CA
  • UC San Diego Medical Center - Encinitas · Encinitas, CA
  • City of Hope Lennar Foundation Cancer Center · Irvine, CA
  • UC San Diego Koman Family Outpatient Pavilion · La Jolla, CA
  • UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) · La Jolla, CA
  • UC San Diego Moores Cancer Center · La Jolla, CA
  • UC San Diego Sulpizio Cardiovascular Center · La Jolla, CA
  • UC San Diego McGrath Outpatient Pavilion - Hillcrest · San Diego, CA
  • UC San Diego Medical Center - Bankers Hill · San Diego, CA
  • UC San Diego Medical Center - Rancho Bernardo · San Diego, CA
  • UC San Diego Medical Center- Hillcrest · San Diego, CA
  • UC San Diego Medical Center - Vista · Vista, CA

Illinois · 2

  • Hope and Healing Clinical Research · Hinsdale, IL
  • Hope and Healing Clinical Research · New Lenox, IL

New Jersey · 3

  • MSK Basking Ridge · Basking Ridge, NJ
  • MSK Monmouth · Middletown, NJ
  • MSK Bergen. · Montvale, NJ

New York · 6

  • MSK Commack · Commack, NY
  • MSK Westchester · Harrison, NY
  • Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy · Long Island City, NY
  • Memorial Sloan Kettering Cancer Center · New York, NY
  • Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street). · New York, NY
  • MSK Nassau · Uniondale, NY

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.