Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL
NCT07321652
This study is recruiting at 218 US sites in 31 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of adding sonrotoclax to zanubrutinib versus zanubrutinib alone for the treatment of patients with untreated chronic lymphoblastic leukemia (CLL)/small lymphocytic lymphoma (SLL). Sonrotoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib is in a class of medications called kinase inhibitors.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Chronic Lymphocytic Leukemia
- Small Lymphocytic Leukemia
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Alliance for Clinical Trials in Oncology
- Last updated on ClinicalTrials.gov
- October 2, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
California · 15
- Kaiser Permanente-Anaheim · Anaheim, CA
- Kaiser Permanente-Baldwin Park · Baldwin Park, CA
- Kaiser Permanente-Bellflower · Bellflower, CA
- Kaiser Permanente-Fontana · Fontana, CA
- Kaiser Permanente South Bay · Harbor City, CA
- Kaiser Permanente-Irvine · Irvine, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Kaiser Permanente West Los Angeles · Los Angeles, CA
- Kaiser Permanente-Ontario · Ontario, CA
- Kaiser Permanente - Panorama City · Panorama City, CA
- Kaiser Permanente-Riverside · Riverside, CA
- Kaiser Permanente-San Diego Zion · San Diego, CA
- Kaiser Permanente-San Marcos · San Marcos, CA
- Kaiser Permanente-Woodland Hills · Woodland Hills, CA
Colorado · 3
- Kaiser Permanente-Franklin · Denver, CO
- Kaiser Permanente-Rock Creek · Lafayette, CO
- Kaiser Permanente-Lone Tree · Lone Tree, CO
Delaware · 2
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
Florida · 12
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Coral Springs · Coral Springs, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, FL
- UM Sylvester Comprehensive Cancer Center at Hollywood · Hollywood, FL
- Jupiter Medical Center · Jupiter, FL
- The Watson Clinic · Lakeland, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- Mount Sinai Medical Center · Miami Beach, FL
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia · North Miami, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
Idaho · 7
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Idaho Urologic Institute-Meridian · Meridian, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 30
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Northwestern University · Chicago, IL
- University of Illinois · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Carle Physician Group-Effingham · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Carle BroMenn Medical Center · Normal, IL
- Carle Cancer Institute Normal · Normal, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Memorial Hospital East · Shiloh, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Illinois CancerCare - Washington · Washington, IL
Iowa · 17
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Saint Anthony Regional Hospital · Carroll, IA
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- UI Healthcare Mission Cancer and Blood - Fort Dodge · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
- UI Healthcare Mission Cancer and Blood - Pella · Pella, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kansas · 24
- Cancer Center of Kansas - Chanute · Chanute, KS
- Cancer Center of Kansas - Dodge City · Dodge City, KS
- Cancer Center of Kansas - El Dorado · El Dorado, KS
- HaysMed · Hays, KS
- Cancer Center of Kansas-Independence · Independence, KS
- University of Kansas Cancer Center · Kansas City, KS
- Cancer Center of Kansas-Kingman · Kingman, KS
- Lawrence Memorial Hospital · Lawrence, KS
- Cancer Center of Kansas-Liberal · Liberal, KS
- Cancer Center of Kansas - McPherson · McPherson, KS
- Cancer Center of Kansas - Newton · Newton, KS
- The University of Kansas Cancer Center - Olathe · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- Cancer Center of Kansas - Parsons · Parsons, KS
- Cancer Center of Kansas - Pratt · Pratt, KS
- Cancer Center of Kansas - Salina · Salina, KS
- Salina Regional Health Center · Salina, KS
- University of Kansas Health System Saint Francis Campus · Topeka, KS
- Cancer Center of Kansas - Wellington · Wellington, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
- Ascension Via Christi Hospitals Wichita · Wichita, KS
- Cancer Center of Kansas - Wichita · Wichita, KS
- Cancer Center of Kansas-Wichita Medical Arts Tower · Wichita, KS
- Cancer Center of Kansas - Winfield · Winfield, KS
Kentucky · 2
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Maine · 2
- MaineHealth Maine Medical Center - Portland · Portland, ME
- MaineHealth Cancer Care and IV Therapy - South Portland · South Portland, ME
Massachusetts · 1
- Dana-Farber Cancer Institute · Boston, MA
Michigan · 7
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 12
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Essentia Health Saint Joseph's Medical Center · Brainerd, MN
- Mercy Hospital · Coon Rapids, MN
- Essentia Health - Deer River Clinic · Deer River, MN
- Essentia Health Cancer Center · Duluth, MN
- Essentia Health Hibbing Clinic · Hibbing, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Essentia Health Sandstone · Sandstone, MN
- Essentia Health Virginia Clinic · Virginia, MN
Mississippi · 1
- Baptist Memorial Hospital and Cancer Center-Desoto · Southhaven, MS
Missouri · 14
- Saint Francis Medical Center · Cape Girardeau, MO
- Siteman Cancer Center at Saint Peters Hospital · City of Saint Peters, MO
- Siteman Cancer Center at West County Hospital · Creve Coeur, MO
- Parkland Health Center - Farmington · Farmington, MO
- University Health Truman Medical Center · Kansas City, MO
- University of Kansas Cancer Center - Briarcliff · Kansas City, MO
- University of Kansas Cancer Center - North · Kansas City, MO
- University of Kansas Cancer Center - Lee's Summit · Lee's Summit, MO
- Sainte Genevieve County Memorial Hospital · Sainte Genevieve, MO
- Missouri Baptist Medical Center · St Louis, MO
- Siteman Cancer Center at Christian Hospital · St Louis, MO
- Siteman Cancer Center-South County · St Louis, MO
- Washington University School of Medicine · St Louis, MO
- Missouri Baptist Sullivan Hospital · Sullivan, MO
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.