Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
NCT07291037
This study is recruiting at 48 US sites in 25 states, according to its ClinicalTrials.gov record last updated .
Summary
TROPION-Lung17 will measure the efficacy and safety of datopotamab deruxtecan (Dato-DXd) compared with docetaxel in patients with trophoblast cell surface protein 2 (TROP2) positive advanced or metastatic lung cancer without actionable genomic alterations (AGA).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Non-small Cell Lung Cancer (NSCLC)
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- AstraZeneca
- Last updated on ClinicalTrials.gov
- October 13, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 3
- Research Site · Chandler, AZ
- Research Site · Gilbert, AZ
- Research Site · Goodyear, AZ
California · 6
- Research Site · Duarte, CA
- Research Site · Irvine, CA
- Research Site · La Jolla, CA
- Research Site · Loma Linda, CA
- Research Site · Los Angeles, CA
- Research Site · San Diego, CA
Colorado · 2
- Research Site · Grand Junction, CO
- Research Site · Wheat Ridge, CO
Delaware · 1
- Research Site · Newark, DE
Florida · 5
- Research Site · Fort Myers, FL
- Research Site · Jacksonville, FL
- Research Site · St. Petersburg, FL
- Research Site · Tampa, FL
- Research Site · West Palm Beach, FL
Georgia · 2
- Research Site · Marietta, GA
- Research Site · Newnan, GA
Illinois · 5
- Research Site · Chicago, IL
- Research Site · Chicago, IL
- Research Site · Hinsdale, IL
- Research Site · Niles, IL
- Research Site · Zion, IL
Kentucky · 1
- Research Site · Louisville, KY
Maine · 1
- Research Site · South Portland, ME
Maryland · 2
- Research Site · Baltimore, MD
- Research Site · Brandywine, MD
Massachusetts · 1
- Research Site · Boston, MA
Michigan · 1
- Research Site · Detroit, MI
Minnesota · 1
- Research Site · Rochester, MN
Missouri · 1
- Research Site · Bridgeton, MO
Nebraska · 1
- Research Site · Lincoln, NE
New Mexico · 1
- Research Site · Albuquerque, NM
New York · 1
- Research Site · East Syracuse, NY
Pennsylvania · 2
- Research Site · Hershey, PA
- Research Site · Lancaster, PA
South Carolina · 1
- Research Site · Greenville, SC
Tennessee · 1
- Research Site · Memphis, TN
Texas · 3
- Research Site · Austin, TX
- Research Site · Denton, TX
- Research Site · Plano, TX
Virginia · 3
- Research Site · Charlottesville, VA
- Research Site · Fairfax, VA
- Research Site · Williamsburg, VA
Washington · 1
- Research Site · Tacoma, WA
West Virginia · 1
- Research Site · Morgantown, WV
Wisconsin · 1
- Research Site · Eau Claire, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.