A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)
NCT07288138
This study is recruiting at 67 US sites in 17 states, according to its ClinicalTrials.gov record last updated .
Summary
The primary objective of this trial is to evaluate the dose-dependent and comparative effects of ECC4703 (low and high dose), ECC0509 (low and high dose), and their combination on hepatic fat reduction as assessed by change in magnetic resonance imaging proton density fat fraction (MRI-PDFF) at Week 12.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metabolic Dysfunction-associated Steatohepatitis
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Eccogene
- Last updated on ClinicalTrials.gov
- October 9, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 4
- Arizona Liver Health · Chandler, AZ
- Arizona Liver Health - Peoria · Peoria, AZ
- Adobe Clinical Research, LLC · Tucson, AZ
- Arizona Liver Health - Tucson · Tucson, AZ
Arkansas · 2
- ARcare Center for Clinical Research · Little Rock, AR
- Arkansas Gastroenterology, P.A · Little Rock, AR
California · 7
- Om Research · Apple Valley, CA
- ARK Clinical Research - Fountain Valley · Fountain Valley, CA
- UCSD Medical Center · La Jolla, CA
- Om Research · Lancaster, CA
- Ark Clinical Research · Long Beach, CA
- Knowledge Research Center · Orange, CA
- Om Research · Victorville, CA
Florida · 9
- Synergy Healthcare · Bradenton, FL
- Synergy Healthcare · Bradenton, FL
- Health Awareness, Inc. · Jupiter, FL
- Evolution Clinical Trials · Miami, FL
- Floridian Clinical Research, LLC · Miami Lakes, FL
- Ocala GI Research · Ocala, FL
- Progressive Medical Research · Port Orange, FL
- ClinCloud, LLC · Viera, FL
- Metabolic Research Institute · West Palm Beach, FL
Georgia · 2
- CenExel - iResearch · Decatur, GA
- Gastrointestinal Specialists of Georgia, PC · Marietta, GA
Illinois · 2
- GI Alliance Glenview · Glenview, IL
- GI Alliance Gurnee · Gurnee, IL
Indiana · 1
- Digestive Research Alliance of Michiana · South Bend, IN
Louisiana · 7
- Tandem Clinical Research · Covington, LA
- Tandem Clinical Research · Houma, LA
- Tandem Clinical Research GI, LLC · Marrero, LA
- Tandem Clinical Research · Metairie, LA
- Delta Research Partners · Monroe, LA
- Louisiana Research Center, LLC · Shreveport, LA
- Delta Research Partners, LLC · West Monroe, LA
Maryland · 1
- Mid-Atlantic GI Research · Greenbelt, MD
Missouri · 2
- Gastrointestinal Associates · Columbia, MO
- Gateway GI Research, LLC · St Louis, MO
Nevada · 1
- Jubilee Clinical Research, Inc · Las Vegas, NV
New Jersey · 2
- Clinical Research Integrity (CRI) Lifetree, LLC · Marlton, NJ
- Premier Health Research · Sparta, NJ
North Carolina · 1
- Coastal Research Institute · Fayetteville, NC
Ohio · 4
- Akron Gastro Research · Akron, OH
- Digestive Specialists · Dayton, OH
- DSI Research · Springboro, OH
- Clinical Research Institute of Ohio (CRIOH), LLC · Westlake, OH
South Carolina · 1
- Columbia Gastroenterology Associates, Llc · Columbia, SC
Texas · 19
- Pinnacle Clinical Research · Austin, TX
- Bellaire Clinical Research · Bellaire, TX
- South Texas Research Institute (STRI) - Brownsville · Brownsville, TX
- Pinnacle Clinical Research · Corpus Christi, TX
- South Texas Research Institute (STRI) · Edinburg, TX
- Dallas Research Institute, LLC · Farmers Branch, TX
- Care United Research · Forney, TX
- Evidentis Clinical Research · Fort Worth, TX
- GI Alliance Digestive Health Associates of Texas - Garland · Garland, TX
- Pinnacle Clinical Research - Georgetown · Georgetown, TX
- Houston Research Institute · Houston, TX
- Houston Research Institute - Medical Center · Houston, TX
- Houston Research Institute - Pasadena · Pasadena, TX
- Pinnacle Clinical Research · San Antonio, TX
- Pinnacle Clinical Research - South San Antonio · San Antonio, TX
- Quality Research, Inc. · San Antonio, TX
- Sugarland Medical Associates (Sma) · Sugar Land, TX
- GI Alliance Webster · Webster, TX
- Digestive Health Research of North Texas, LLC · Wichita Falls, TX
Virginia · 2
- GI Alliance Richmond · Richmond, VA
- GI Select Health Research · Richmond, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.