Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma
NCT07281417
This study is recruiting at 18 US sites in 8 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial compares the effect of chemotherapy (carboplatin and paclitaxel) with versus without cemiplimab given before surgery (neoadjuvant) in patients with sinonasal squamous cell cancer. Carboplatin is in a class of medications known as platinum-containing compounds. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Sinonasal Squamous Cell Carcinoma
- Stage III Sinonasal Cancer AJCC v8
- Stage IVA Sinonasal Cancer AJCC v8
- Stage IVB Sinonasal Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 5, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 4
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
Connecticut · 4
- Yale University · New Haven, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Florida · 5
- Moffitt Cancer Center at SouthShore · Ruskin, FL
- Moffitt Cancer Center · Tampa, FL
- Moffitt Cancer Center - McKinley Campus · Tampa, FL
- Moffitt Cancer Center-International Plaza · Tampa, FL
- Moffitt Cancer Center at Wesley Chapel · Wesley Chapel, FL
Georgia · 1
- Emory University Hospital Midtown · Atlanta, GA
Kentucky · 1
- University of Kentucky/Markey Cancer Center · Lexington, KY
North Carolina · 1
- UNC Lineberger Comprehensive Cancer Center · Chapel Hill, NC
Pennsylvania · 1
- UPMC Hillman Cancer Center · Pittsburgh, PA
Virginia · 1
- University of Virginia Cancer Center · Charlottesville, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.