Evaluating the Safety and Tolerability of Baricitinib in Patients With Job Syndrome With Lupus-Like Disease and/or Atopic Dermatitis

Summary

Background: Autosomal dominant hyper-IgE syndrome (HIES), also called Job syndrome, is a genetic disorder that affects the immune system. It can cause skin and lung infections and problems with blood vessels, connective tissues, and bones. People with HIES often have lupus-like disease or atopic dermatitis (skin rash). Researchers want to know if a drug approved to treat other immune system diseases (baricitinib) can help people with HIES. Objective: To test baricitinib in people with HIES with lupus-like disease or skin rash.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Hyper IgE Syndrome From STAT3 Mutation
• Job s Syndrome
• HIES
• Lupus
• Atopic Dermatitis

Eligibility basics and study details

Study type

Interventional

Phase

Phase 1

Ages

12 to 120 years

Sex

All

Healthy volunteers

Not accepted

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Last updated on ClinicalTrials.gov

October 15, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites