Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
NCT07228832
This study is recruiting at 112 US sites in 37 states, according to its ClinicalTrials.gov record last updated .
Summary
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer(HARMONi-GI3)
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Colorectal Cancer (CRC)
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Summit Therapeutics
- Last updated on ClinicalTrials.gov
- October 6, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 2
- Clinical Study Site · Mobile, AL
- Clinical Study Site · Tuscaloosa, AL
Arizona · 1
- Clinical Study Site · Goodyear, AZ
California · 24
- Clinical Study Site · Beverly Hills, CA
- Clinical Study Site · Beverly Hills, CA
- Clinical Study Site · Cerritos, CA
- Clinical Study Site · Corona, CA
- Clinical Study Site · Duarte, CA
- Clinical Study Site · Fountain Valley, CA
- Clinical Study Site · Huntington Beach, CA
- Clinical Study Site · Irvine, CA
- Clinical Study Site · Irvine, CA
- Clinical Study Site · Los Angeles, CA
- Clinical Study Site · Los Angeles, CA
- Clinical Study Site · Los Angeles, CA
- Clinical Study Site · Murrieta, CA
- Clinical Study Site · Oakland, CA
- Clinical Study Site · Orange, CA
- Clinical Study Site · Pasadena, CA
- Clinical Study Site · Roseville, CA
- Clinical Study Site · San Francisco, CA
- Clinical Study Site · Santa Clara, CA
- Clinical Study Site · Stanford, CA
- Clinical Study Site · Torrance, CA
- Clinical Study Site · Upland, CA
- Clinical Study Site · Vallejo, CA
- Clinical Study Site · West Hollywood, CA
Colorado · 4
- Clinical Study Site · Aurora, CO
- Clinical Study Site · Denver, CO
- Clinical Study Site · Highlands Ranch, CO
- Clinical Study Site · Lone Tree, CO
Connecticut · 3
- Clinical Study Site · Hartford, CT
- Clinical Study Site · New Haven, CT
- Clinical Study Site · Norwich, CT
Delaware · 1
- Clinical Study Site · Newark, DE
Florida · 10
- Clinical Study Site · Hialeah, FL
- Clinical Study Site · Miami, FL
- Clinical Study Site · Miami Beach, FL
- Clinical Study Site · Ocala, FL
- Clinical Study Site · Orlando, FL
- Clinical Study Site · Orlando, FL
- Clinical Study Site · Plantation, FL
- Clinical Study Site · Port Saint Lucie, FL
- Clinical Study Site · St. Petersburg, FL
- Clinical Study Site · Tamarac, FL
Georgia · 3
- Clinical Study Site · Atlanta, GA
- Clinical Study Site · Atlanta, GA
- Clinical Study Site · Newnan, GA
Illinois · 4
- Clinical Study Site · Chicago, IL
- Clinical Study Site · Chicago, IL
- Clinical Study Site · Elmhurst, IL
- Clinical Study Site · O'Fallon, IL
Indiana · 2
- Clinical Study Site · Fort Wayne, IN
- Clinical Study Site · Indianapolis, IN
Kansas · 1
- Clinical Study Site · Westwood, KS
Kentucky · 1
- Clinical Study Site · Edgewood, KY
Louisiana · 1
- Clinical Study Site · New Orleans, LA
Maryland · 1
- Clinical Study Site · Baltimore, MD
Massachusetts · 3
- Clinical Study Site · Boston, MA
- Clinical Study Site · Danvers, MA
- Clinical Study Site · Newton, MA
Michigan · 1
- Clinical Study Site · Detroit, MI
Minnesota · 2
- Clinical Study Site · Minneapolis, MN
- Clinical Study Site · Saint Louis Park, MN
Missouri · 1
- Clinical Study Site · Springfield, MO
Montana · 1
- Clinical Study Site · Billings, MT
Nebraska · 1
- Clinical Study Site · Lincoln, NE
New Hampshire · 1
- Clinical Study Site · Lebanon, NH
New Jersey · 2
- Clinical Study Site · Camden, NJ
- Clinical Study Site · New Brunswick, NJ
New York · 6
- Clinical Study Site · Mineola, NY
- Clinical Study Site · New York, NY
- Clinical Study Site · Rochester, NY
- Clinical Study Site · Syracuse, NY
- Clinical Study Site · The Bronx, NY
- Clinical Study Site · White Plains, NY
North Carolina · 1
- Clinical Study Site · Pinehurst, NC
Ohio · 7
- Clinical Study Site · Akron, OH
- Clinical Study Site · Canton, OH
- Clinical Study Site · Cincinnati, OH
- Clinical Study Site · Cincinnati, OH
- Clinical Study Site · Cleveland, OH
- Clinical Study Site · Cleveland, OH
- Clinical Study Site · Mayfield Heights, OH
Oklahoma · 1
- Clinical Study Site · Oklahoma City, OK
Pennsylvania · 7
- Clinical Study Site · Lebanon, PA
- Clinical Study Site · Philadelphia, PA
- Clinical Study Site · Philadelphia, PA
- Clinical Study Site · Philadelphia, PA
- Clinical Study Site · Pittsburgh, PA
- Clinical Study Site · Pittsburgh, PA
- Clinical Study Site · Sellersville, PA
Rhode Island · 1
- Clinical Study Site · Providence, RI
South Carolina · 2
- Clinical Study Site · Greenville, SC
- Clinical Study Site · Spartanburg, SC
Tennessee · 2
- Clinical Study Site · Germantown, TN
- Clinical Study Site · Hermitage, TN
Texas · 6
- Clinical Study Site · Dallas, TX
- Clinical Study Site · Dallas, TX
- Clinical Study Site · Fort Worth, TX
- Clinical Study Site · Houston, TX
- Clinical Study Site · Houston, TX
- Clinical Study Site · Tyler, TX
Utah · 2
- Clinical Study Site · Salt Lake City, UT
- Clinical Study Site · Salt Lake City, UT
Vermont · 1
- Clinical Study Site · Burlington, VT
Virginia · 2
- Clinical Study Site · Charlottesville, VA
- Clinical Study Site · Fairfax, VA
Washington · 2
- Clinical Study Site · Spokane, WA
- Clinical Study Site · Tacoma, WA
West Virginia · 1
- Clinical Study Site · Charleston, WV
Wisconsin · 1
- Clinical Study Site · Madison, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.