Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer
NCT07215910
This study is recruiting at 176 US sites in 33 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of vorasidenib to placebo in combination with usual treatment, temozolomide, in treating patients with newly diagnosed grade 3 astrocytoma after radiation. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid and may kill tumor cells and slow down or stop tumor growth. Vorasidenib citrate blocks the proteins made by the mutated IDH1 and IDH2 genes, which may help keep tumor cells from growing. It is a type of enzyme inhibitor and a type of targeted therapy.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Astrocytoma, IDH-Mutant, Grade 3
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 12 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Alliance for Clinical Trials in Oncology
- Last updated on ClinicalTrials.gov
- November 3, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Saint Joseph's Hospital and Medical Center · Phoenix, AZ
California · 28
- Kaiser Permanente-Anaheim · Anaheim, CA
- AIS Cancer Center at San Joaquin Community Hospital · Bakersfield, CA
- Kaiser Permanente-Bellflower · Bellflower, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- Kaiser Permanente Dublin · Dublin, CA
- Kaiser Permanente-Fremont · Fremont, CA
- Kaiser Permanente Fresno Orchard Plaza · Fresno, CA
- Kaiser Permanente-Fresno · Fresno, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Kaiser Permanente- Modesto MOB II · Modesto, CA
- Kaiser Permanente-Oakland · Oakland, CA
- Kaiser Permanente-Ontario · Ontario, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Kaiser Permanente-Roseville · Roseville, CA
- Kaiser Permanente Downtown Commons · Sacramento, CA
- Kaiser Permanente-South Sacramento · Sacramento, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Kaiser Permanente-San Francisco · San Francisco, CA
- Kaiser Permanente-Santa Teresa-San Jose · San Jose, CA
- Kaiser Permanente San Leandro · San Leandro, CA
- Kaiser San Rafael-Gallinas · San Rafael, CA
- Kaiser Permanente Medical Center - Santa Clara · Santa Clara, CA
- Kaiser Permanente-Santa Rosa · Santa Rosa, CA
- Kaiser Permanente-South San Francisco · South San Francisco, CA
- Kaiser Permanente-Vallejo · Vallejo, CA
- John Muir Medical Center-Walnut Creek · Walnut Creek, CA
- Kaiser Permanente-Walnut Creek · Walnut Creek, CA
Colorado · 4
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- Medical Center of the Rockies · Loveland, CO
Connecticut · 3
- Yale University · New Haven, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 2
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
Florida · 10
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Coral Springs · Coral Springs, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, FL
- UM Sylvester Comprehensive Cancer Center at Hollywood · Hollywood, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia · North Miami, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
- Tampa General Hospital · Tampa, FL
Georgia · 1
- Augusta University Medical Center · Augusta, GA
Illinois · 27
- Illinois CancerCare-Bloomington · Bloomington, IL
- OSF Saint Joseph Medical Center · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Rush MD Anderson Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Carle Physician Group-Effingham · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- NorthShore University HealthSystem-Highland Park Hospital · Highland Park, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Rush MD Anderson Cancer Center at Rush Oak Park · Oak Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- OSF Saint Francis Medical Center · Peoria, IL
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Carle Cancer Center · Urbana, IL
- Illinois CancerCare - Washington · Washington, IL
- Midwestern Regional Medical Center · Zion, IL
Iowa · 9
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- UI Healthcare Mission Cancer and Blood - Pella · Pella, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kansas · 5
- University of Kansas Cancer Center · Kansas City, KS
- Lawrence Memorial Hospital · Lawrence, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- University of Kansas Hospital-Indian Creek Campus · Overland Park, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Kentucky · 2
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Louisiana · 4
- West Jefferson Medical Center · Marrero, LA
- East Jefferson General Hospital · Metairie, LA
- Children's Hospital New Orleans · New Orleans, LA
- University Medical Center New Orleans · New Orleans, LA
Maine · 4
- MaineHealth Coastal Cancer Treatment Center · Bath, ME
- MaineHealth Maine Medical Center - Portland · Portland, ME
- MaineHealth Cancer Care Center of York County · Sanford, ME
- MaineHealth Maine Medical Center- Scarborough · Scarborough, ME
Massachusetts · 3
- Dana-Farber Cancer Institute · Boston, MA
- Massachusetts General Hospital Cancer Center · Boston, MA
- Tufts Medical Center · Boston, MA
Michigan · 5
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- University of Michigan - Brighton Center for Specialty Care · Brighton, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital · Grand Rapids, MI
- University of Michigan Health - West · Wyoming, MI
Minnesota · 6
- Mercy Hospital · Coon Rapids, MN
- Fairview Southdale Hospital · Edina, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Coborn Cancer Center at Saint Cloud Hospital · Saint Cloud, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
Mississippi · 1
- University of Mississippi Medical Center · Jackson, MS
Missouri · 9
- Siteman Cancer Center at Saint Peters Hospital · City of Saint Peters, MO
- Siteman Cancer Center at West County Hospital · Creve Coeur, MO
- University of Kansas Cancer Center - Briarcliff · Kansas City, MO
- University of Kansas Cancer Center - North · Kansas City, MO
- University of Kansas Cancer Center - Lee's Summit · Lee's Summit, MO
- Mercy Hospital Springfield · Springfield, MO
- Siteman Cancer Center at Christian Hospital · St Louis, MO
- Siteman Cancer Center-South County · St Louis, MO
- Washington University School of Medicine · St Louis, MO
New Hampshire · 1
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH
New Jersey · 6
- Memorial Sloan Kettering Basking Ridge · Basking Ridge, NJ
- Hackensack University Medical Center · Hackensack, NJ
- Memorial Sloan Kettering Monmouth · Middletown, NJ
- Memorial Sloan Kettering Bergen · Montvale, NJ
- Morristown Medical Center · Morristown, NJ
- Overlook Hospital · Summit, NJ
New York · 12
- Northwell Health Imbert Cancer Center · Bay Shore, NY
- NYU Langone Hospital - Brooklyn · Brooklyn, NY
- Memorial Sloan Kettering Commack · Commack, NY
- Memorial Sloan Kettering Westchester · Harrison, NY
- Northwell Health/Center for Advanced Medicine · Lake Success, NY
- NYU Langone Hospital - Long Island · Mineola, NY
- Northern Westchester Hospital · Mount Kisco, NY
- Laura and Isaac Perlmutter Cancer Center at NYU Langone · New York, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center · New York, NY
- Stony Brook University Medical Center · Stony Brook, NY
- Memorial Sloan Kettering Nassau · Uniondale, NY
North Carolina · 1
- Duke University Medical Center · Durham, NC
Ohio · 3
- University of Cincinnati Cancer Center-UC Medical Center · Cincinnati, OH
- Ohio State University Comprehensive Cancer Center · Columbus, OH
- University of Cincinnati Cancer Center-West Chester · West Chester, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Oregon · 2
- Providence Portland Medical Center · Portland, OR
- Providence Saint Vincent Medical Center · Portland, OR
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.