A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
NCT07190248
This study is recruiting at 14 US sites in 10 states, according to its ClinicalTrials.gov record last updated .
Summary
Researchers want to learn if the study medicines calderasib and subcutaneous (SC) pembrolizumab can be used to treat non-small cell lung cancer (NSCLC) when given together. Calderasib is a targeted therapy for the KRAS G12C mutation. The goal of this study is to learn if people who receive calderasib with SC pembrolizumab live longer without the cancer growing or spreading than in people who receive SC pembrolizumab with chemotherapy.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Non-small Cell Lung Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Merck Sharp & Dohme LLC
- Last updated on ClinicalTrials.gov
- October 7, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- Central Alabama Research ( Site 0108) · Birmingham, AL
Connecticut · 2
- University of Connecticut Health Center ( Site 0130) · Farmington, CT
- Stamford Hospital ( Site 0126) · Stamford, CT
Georgia · 1
- Low Country Cancer Care ( Site 0156) · Savannah, GA
Indiana · 1
- Indiana University Health Arnett Cancer Center ( Site 0116) · Lafayette, IN
Maine · 1
- New England Cancer Specialists ( Site 0139) · Westbrook, ME
New Jersey · 1
- John Theurer Cancer Center at Hackensack University Medical Center ( Site 0152) · Hackensack, NJ
New York · 2
- New York Oncology Hematology, P.C. ( Site 0119) · Albany, NY
- Wilmot Cancer Institute ( Site 0141) · Rochester, NY
Oregon · 1
- St. Charles Health System, Inc ( Site 0146) · Bend, OR
Pennsylvania · 1
- Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0111) · Lancaster, PA
Virginia · 3
- Hematology Oncology Associates of Fredericksburg ( Site 9550) · Fredericksburg, VA
- Bon Secours Cancer Institute at St. Francis ( Site 0148) · Midlothian, VA
- Blue Ridge Cancer Care ( Site 0144) · Roanoke, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.