DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment
NCT07158164
This study is recruiting at 12 US sites in 1 state, according to its ClinicalTrials.gov record last updated .
Summary
To prospectively evaluate the efficacy and safety of DPYD-guided dosing strategies in a real-world clinical setting, specifically by comparing the incidence of severe (Grade 3 and 4) fluoropyrimidine-related toxicities of heterozygous DPYD variant patients assigned to DPYD-guided reduced dosing versus patients with standard dosing in the control arm.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Colorectal Neoplasms
- Breast Neoplasms
- Head and Neck Neoplasms
- Gastro-Intestinal Intraepithelial Neoplasia
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 4
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Rutgers, The State University of New Jersey
- Last updated on ClinicalTrials.gov
- November 13, 2025
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
New Jersey · 12
- RWJBarnabas Health Clara Maas Medical Center · Belleville, NJ
- Trinitas Hospital and Comprehensive Cancer Center · Elizabeth, NJ
- RWJBarnabas Health - Robert Wood Johnson University Hospital, Hamilton · Hamilton, NJ
- RWJBarnabas Health Jersey City Medical Center · Jersey City, NJ
- Cooperman Barnabas Medical Center · Livingston, NJ
- Jack and Sheryl Morris Cancer Center · New Brunswick, NJ
- RWJBarnabas Health - Robert Wood Johnson University Hospita · New Brunswick, NJ
- Cancer Center Initiative · Newark, NJ
- RWJBarnabas Health Newark Beth Israel Medical Center · Newark, NJ
- University Hospital · Newark, NJ
- RWJBarnabas Health - Robert Wood Johnson University Hospital Somerset · Somerville, NJ
- RWJBarnabas Health - Community Medical Center · Toms River, NJ
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.