A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT07154290
This study is recruiting at 17 US sites in 13 states, according to its ClinicalTrials.gov record last updated .
Summary
This study will evaluate two study drugs called ubamatamab and marlotamig, to see if they can help treat advanced or metastatic Non-Small Cell Lung Cancer (NSCLC), and sarilumab, to evaluate to see if it can help with immune-related side effects from ubamatamab. The study is looking at: How well ubamatamab and marlotamig work(s) The side effects that ubamatamab and marlotamig might cause How much ubamatamab and marlotamig is in the blood at different times If the body makes antibodies to ubamatamab and/or marlotamig, this may cause the ubamatamab to not work as well
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Non Small Cell Lung Cancer
- Advanced Non Small Cell Lung Cancer
- Metastatic Non Small Cell Lung Cancer
- Carcinoma Non Small Cell Lung
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Regeneron Pharmaceuticals
- Last updated on ClinicalTrials.gov
- September 25, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham · Birmingham, AL
Arizona · 1
- Cancer Treatment Centers of America, Phoenix · Goodyear, AZ
California · 1
- The City of Hope Orange County Lennar Foundation Cancer Center · Irvine, CA
Delaware · 1
- ChristianaCare Health System · Newark, DE
District of Columbia · 1
- Georgetown University · Washington D.C., DC
Florida · 1
- Mayo Clinic Jacksonville · Jacksonville, FL
Illinois · 2
- Rush University Medical Center · Chicago, IL
- University of Illinois Chicago · Chicago, IL
Indiana · 1
- Franciscan Health · Munster, IN
Maryland · 1
- University of Maryland Greenebaum Comprehensive Cancer Center · Baltimore, MD
Minnesota · 1
- Mayo Clinic · Rochester, MN
Missouri · 1
- Washington University School of Medicine · St Louis, MO
Tennessee · 2
- University of Tennessee Medical Center · Knoxville, TN
- Sarah Cannon Research Institute · Nashville, TN
Texas · 3
- University of Texas Medical Branch · Galveston, TX
- The University of Texas MD Anderson Cancer Center · Houston, TX
- Baylor Scott & White Health · Temple, TX
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.