OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
NCT07136012
This study is recruiting at 194 US sites in 38 states, according to its ClinicalTrials.gov record last updated .
Summary
The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp[a]).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Cardiovascular Disease
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 50 to 105 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Amgen
- Last updated on ClinicalTrials.gov
- August 21, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 7
- Advanced Cardiovascular LLC · Alexander City, AL
- Birmingham Clinical Research · Birmingham, AL
- University of Alabama Birmingham Saint Vincents Birmingham · Birmingham, AL
- Alliance For Multispecialty Research - Daphne · Daphne, AL
- Eastern Shore Research Institute · Fairhope, AL
- Heart Center Research LLC · Huntsville, AL
- CB Flock Research Corporation · Mobile, AL
Arizona · 5
- Elite Clinical Studies LLC · Phoenix, AZ
- Hero Clinical Research · Phoenix, AZ
- Phoenix Clinical · Phoenix, AZ
- HonorHealth Research Institute · Scottsdale, AZ
- Eclipse Clinical Research · Tucson, AZ
Arkansas · 1
- Lynn Institute of the Ozarks · Little Rock, AR
California · 14
- National Heart Institute · Beverly Hills, CA
- 310 Clinical Research · Inglewood, CA
- University of California San Diego · La Jolla, CA
- InvivoCure · Los Angeles, CA
- Valley Clinical Trials · Northridge, CA
- Clinical Trials Research - Sacramento · Roseville, CA
- Alliance Clinical Research · San Diego, CA
- Encompass Clinical Research · Spring Valley, CA
- Stanford Health Care · Stanford, CA
- Manshadi Heart Institute · Stockton, CA
- Blue Coast Cardiology · Vista, CA
- Diablo Clinical Research · Walnut Creek, CA
- Focus Clinical Research · West Hills, CA
- Interventional Cardiology Medical Group · West Hills, CA
Colorado · 2
- UCHealth Memorial Central · Colorado Springs, CO
- South Denver Cardiology Associates · Littleton, CO
Connecticut · 3
- Gandelman Cardiology, PC · Greenwich, CT
- ClinTrial Hamden · Hamden, CT
- Chase Medical Research LLC · Waterbury, CT
Florida · 17
- Excel Medical Clinical Trials · Boca Raton, FL
- Clearwater Cardiovascular Consultants · Clearwater, FL
- Jacksonville Center for Clinical Research · Jacksonville, FL
- East Coast Institute for Research, LLC · Lake City, FL
- Columbus Clinical Services LLC · Miami, FL
- Kendall South Medical Center · Miami, FL
- Indago Research and Health Center · Miami Lakes, FL
- Inpatient Research Clinic, LLC · Miami Lakes, FL
- Panax Clinical Research · Miami Lakes, FL
- Eminat, LLC · Miramar, FL
- Suncoast Clinical Research Inc · New Port Richey, FL
- Ocala Cardiovascular Research · Ocala, FL
- Ocala Research Institute, Inc · Ocala, FL
- Ormond Beach Clinical Research · Ormond Beach, FL
- Baptist Health Care · Pensacola, FL
- Denali Health Plant City · Plant City, FL
- Clinical Site Partners Orlando dba Flourish Research · Winter Park, FL
Georgia · 6
- Emory University Hospital · Atlanta, GA
- East Coast Institute for Research · Canton, GA
- Northeast Georgia Medical Center Wisteria Building · Cumming, GA
- Nsc Research · Johns Creek, GA
- Georgia Clinical Research · Lawrenceville, GA
- North Georgia Clinical Research · Woodstock, GA
Idaho · 1
- St Lukes Idaho · Meridian, ID
Illinois · 4
- Endeavor Health-Northwest Community Healthcare · Arlington Heights, IL
- Christie Clinic · Champaign, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Alliance for Multispecialty Research LLC - Park Ridge · Park Ridge, IL
Indiana · 6
- MediSphere Medical Research Center LLC · Evansville, IN
- Parkview Research Center · Fort Wayne, IN
- Ascension Saint Vincent Heart Center · Indianapolis, IN
- Franciscan Health Indianapolis · Indianapolis, IN
- Cardiovascular Research of Northwest Indiana LLC · Munster, IN
- Reid Physician Associates · Richmond, IN
Iowa · 1
- MercyOne Iowa Heart Center · West Des Moines, IA
Kansas · 3
- Hutchinson Clinic PA · Hutchinson, KS
- University of Kansas Medical Center · Kansas City, KS
- Midwest Heart and Vascular Specialists · Overland Park, KS
Kentucky · 3
- Graves Gilbert Clinic · Bowling Green, KY
- Baptist Health Lexington · Lexington, KY
- The Research Group of Lexington LLC · Lexington, KY
Louisiana · 4
- Heart Clinic of Hammond · Covington, LA
- IMA Clinical Research · Monroe, LA
- Louisiana Heart Center · Slidell, LA
- Monroe Research LLC · West Monroe, LA
Maryland · 8
- Ascension Saint Agnes Heart Care · Baltimore, MD
- Johns Hopkins Hospital · Baltimore, MD
- Metropolitan Cardiovascular Consultants LLC · Beltsville, MD
- Flourish Research · Bowie, MD
- Centennial Medical Group · Columbia, MD
- Johns Hopkins University · Columbia, MD
- Capitol Cardiology Associates · Lanham, MD
- MedStar Health Research Institute · Olney, MD
Massachusetts · 1
- Brigham and Womens Hospital · Boston, MA
Michigan · 5
- Henry Ford Health System · Detroit, MI
- Healthy Heart Cardiology · Grand Rapids, MI
- MyMichigan Medical Center Midland - Clinical Research Department · Midland, MI
- Advanced Cardiology Associates · Rochester Hills, MI
- Revival Research Institute · Southfield, MI
Minnesota · 5
- Saint Marys Medical Center · Duluth, MN
- Health East Cancer Care · Maplewood, MN
- University of Minnesota · Minneapolis, MN
- Mayo Clinic · Rochester, MN
- Methodist Hospital · Saint Louis Park, MN
Mississippi · 2
- Jackson Heart Clinic · Jackson, MS
- Cardiology Associates Research LLC · Tupelo, MS
Missouri · 3
- Sisters of Saint Mary Health Heart and Vascular Care · Bridgeton, MO
- Kansas City Veterans Affairs Medical Center · Kansas City, MO
- Washington University · St Louis, MO
Nebraska · 2
- Bryan Heart · Lincoln, NE
- Physician Research Collaboration, LLC · Lincoln, NE
Nevada · 4
- American Institute of Medical Research · Las Vegas, NV
- Excel Clinical Research · Las Vegas, NV
- Las Vegas Clinical Trials · North Las Vegas, NV
- Renown Institute for Heart and Vascular Health · Reno, NV
New Jersey · 10
- Advanced Heart Care LLC · Bridgewater, NJ
- Advanced Heart and Vascular Institute of Hunterdon · Flemington, NJ
- Clinical Reseach Philadelphia Pennington · Hamilton, NJ
- Med Clinical Research Partners - Irvington · Irvington, NJ
- New Jersey Medcare / New Jersey Heart · Linden, NJ
- Saint Michaels Medical Center · Newark, NJ
- Circuit Clinical / Optum Medical Care of New Jersey · Secaucus, NJ
- The Heart House - Washington Township · Sewell, NJ
- CardioMetabolic Collaborative Clinic · Somerset, NJ
- Ima Clinical Research - Warren · Warren Township, NJ
New York · 10
- Albany Medical College · Albany, NY
- Basil Clinical · Inwood, NY
- Rasai Research · Jackson Heights, NY
- Crystal Run Healthcare · Monroe, NY
- Icahn School of Medicine at Mount Sinai · New York, NY
- Mount Sinai Queens · New York, NY
- Niagara Falls Memorial Medical Center · Niagara Falls, NY
- Circuit Clinical Orchard Park Family Practice · Orchard Park, NY
- Hudson Valley Cardiovascular Physicians PC · Poughkeepsie, NY
- Saratoga Clinical Research, LLC · Saratoga Springs, NY
North Carolina · 9
- Duke University Health System · Durham, NC
- Medication Management LLC · Greensboro, NC
- Moses H Cone Memorial Hospital · Greensboro, NC
- Triad Clinical Trials, LLC · Greensboro, NC
- ClinCept, LLC · Kinston, NC
- Monroe Biomedical Research · Monroe, NC
- Piedmont Healthcare · Statesville, NC
- Accellacare Research of Wilmington · Wilmington, NC
- Wake Forest University Health Sciences · Winston-Salem, NC
North Dakota · 1
- Lillestol Research LLC · Fargo, ND
Ohio · 5
- Aultman Cardiology Clinical Trials · Canton, OH
- The Christ Hospital · Cincinnati, OH
- Velocity Clinical Research - Cincinnati · Cincinnati, OH
- Nexgen Research · Lima, OH
- K and R Research · Marion, OH
Oklahoma · 1
- Alliance for Multispecialty Research · Norman, OK
Pennsylvania · 3
- University of Pennsylvania · Philadelphia, PA
- Preferred Primary Care Physicians, Inc · Pittsburgh, PA
- Pottstown Medical Specialists Inc · Pottstown, PA
Rhode Island · 1
- Miriam Hospital · East Greenwich, RI
South Carolina · 3
- Medical University of South Carolina · Charleston, SC
- Pharmacorp Clinical Trials Inc · Charleston, SC
- Prisma Health Carolina Cardiology - Greenville · Gantt, SC
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.