A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)
NCT07111520
This study is recruiting at 11 US sites in 10 states, according to its ClinicalTrials.gov record last updated .
Summary
This is a multi-site, open-label, dose-finding study, consisting of Parts 1, 2a, and 2b to investigate the combination of BNT326 with pumitamig (also known as BNT327 or PM8002) in participants with relapsed, progressive as well as treatment-naïve, advanced/metastatic non-small cell lung cancer (NSCLC). This study will enroll adult participants with histologically or cytologically confirmed NSCLC that is advanced (i.e., either metastatic or recurrent tumors with no known curative treatment available).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Non-small Cell Lung Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1/2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- BioNTech SE
- Last updated on ClinicalTrials.gov
- August 5, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 2
- UCLA Hematology Oncology - Main Site · Los Angeles, CA
- Stanford Cancer Institute · Stanford, CA
Connecticut · 1
- Yale University · New Haven, CT
District of Columbia · 1
- Georgetown University - Lombardi Comprehensive Cancer Center · Washington D.C., DC
Florida · 1
- Moffit Cancer Center · Tampa, FL
Massachusetts · 1
- Dana-Farber Cancer Institute · Boston, MA
Michigan · 1
- Henry Ford Health System · Detroit, MI
New York · 1
- Memorial Sloan Kettering Cancer Center · New York, NY
Ohio · 1
- Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center · Cleveland, OH
Texas · 1
- University of Texas M. D. Anderson Cancer Center · Houston, TX
Virginia · 1
- NEXT Virginia · Fairfax, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.