Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study
NCT07097142
This study is recruiting at 245 US sites in 33 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of decreased number of radiation (ultra-hypofractionated) treatments to the usual radiation number of treatments (hypofractionation) with standard of care chemotherapy, with cisplatin, gemcitabine or mitomycin and 5-fluorouracil for the treatment of patients with muscle invasive bladder cancer. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a short period of time. Ultra-hypofractionated radiation therapy delivers radiation over an even shorter period of time than hypofractionated radiation therapy.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Muscle Invasive Bladder Urothelial Carcinoma
- Stage II Bladder Cancer AJCC v8
- Stage IIIA Bladder Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- NRG Oncology
- Last updated on ClinicalTrials.gov
- October 23, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 1
- Fairbanks Memorial Hospital · Fairbanks, AK
Arkansas · 2
- Mercy Hospital Fort Smith · Fort Smith, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 10
- Tower Cancer Research Foundation · Beverly Hills, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- The Angeles Clinic and Research Institute - West Los Angeles Office · Los Angeles, CA
- UCLA / Jonsson Comprehensive Cancer Center · Los Angeles, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Cedars-Sinai Cancer - Tarzana · Tarzana, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
Colorado · 7
- UCHealth University of Colorado Hospital · Aurora, CO
- AdventHealth Porter · Denver, CO
- UCHealth - Cherry Creek · Denver, CO
- UCHealth Highlands Ranch Hospital · Highlands Ranch, CO
- AdventHealth Littleton · Littleton, CO
- UCHealth Lone Tree Health Center · Lone Tree, CO
- AdventHealth Parker · Parker, CO
Delaware · 7
- Beebe Medical Center · Lewes, DE
- Beebe South Coastal Health Campus · Millville, DE
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
- Christiana Care Health System-Wilmington Hospital · Wilmington, DE
Florida · 8
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, FL
- Miami Cancer Institute · Miami, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia · North Miami, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
Georgia · 4
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
Idaho · 2
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
Illinois · 41
- OSF Saint Anthony's Health Center · Alton, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- OSF Saint Joseph Medical Center · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Northwestern University · Chicago, IL
- Rush MD Anderson Cancer Center · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Elmhurst Memorial Hospital · Elmhurst, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Rush MD Anderson Cancer Center at Rush Lisle · Lisle, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Edward Hospital/Cancer Center · Naperville, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Rush MD Anderson Cancer Center at Rush Oak Park · Oak Park, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- OSF Saint Francis Medical Center · Peoria, IL
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Illinois CancerCare - Washington · Washington, IL
Iowa · 10
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- Mercy Medical Center-West Lakes · West Des Moines, IA
- The Iowa Clinic PC · West Des Moines, IA
Kansas · 8
- Central Care Cancer Center - Garden City · Garden City, KS
- University of Kansas Cancer Center · Kansas City, KS
- Lawrence Memorial Hospital · Lawrence, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- Mercy Hospital Pittsburg · Pittsburg, KS
- University of Kansas Health System Saint Francis Campus · Topeka, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
- Ascension Via Christi Hospitals Wichita · Wichita, KS
Kentucky · 1
- University of Kentucky/Markey Cancer Center · Lexington, KY
Louisiana · 3
- Louisiana Hematology Oncology Associates LLC · Baton Rouge, LA
- Mary Bird Perkins Cancer Center · Baton Rouge, LA
- Mary Bird Perkins Cancer Center - Metairie · Metairie, LA
Massachusetts · 1
- Massachusetts General Hospital Cancer Center · Boston, MA
Michigan · 25
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- University of Michigan - Brighton Center for Specialty Care · Brighton, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Corewell Health Dearborn Hospital · Dearborn, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Hospital · Detroit, MI
- Wayne State University/Karmanos Cancer Institute · Detroit, MI
- Weisberg Cancer Treatment Center · Farmington Hills, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital · Grand Rapids, MI
- Allegiance Health · Jackson, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Henry Ford Medical Center-Columbus · Novi, MI
- Corewell Health Reed City Hospital · Reed City, MI
- Corewell Health William Beaumont University Hospital · Royal Oak, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital · Saint Joseph, MI
- Munson Medical Center · Traverse City, MI
- Corewell Health Beaumont Troy Hospital · Troy, MI
- Henry Ford West Bloomfield Hospital · West Bloomfield, MI
- Henry Ford Wyandotte Hospital · Wyandotte, MI
- University of Michigan Health - West · Wyoming, MI
Minnesota · 20
- Minnesota Oncology - Burnsville · Burnsville, MN
- Minnesota Oncology Hematology PA-Chaska · Chaska, MN
- Mercy Hospital · Coon Rapids, MN
- Minnesota Oncology - Coon Rapids · Coon Rapids, MN
- Fairview Southdale Hospital · Edina, MN
- Minnesota Oncology - Edina · Edina, MN
- Fairview Clinics and Surgery Center Maple Grove · Maple Grove, MN
- Minnesota Oncology - Maple Grove · Maple Grove, MN
- Minnesota Oncology Hematology PA-Maplewood · Maplewood, MN
- Saint John's Hospital - Healtheast · Maplewood, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Hennepin County Medical Center · Minneapolis, MN
- Monticello Cancer Center · Monticello, MN
- North Memorial Medical Health Center · Robbinsdale, MN
- Coborn Cancer Center at Saint Cloud Hospital · Saint Cloud, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Saint Francis Regional Medical Center · Shakopee, MN
- Lakeview Hospital · Stillwater, MN
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.