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A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

NCT07070232

This study is recruiting at 14 US sites in 10 states, according to its ClinicalTrials.gov record last updated .

Summary

This study will evaluate the safety, efficacy, optimal dose, and pharmacokinetics (PK) of BNT326 as monotherapy (Part 1) and as combination treatment with immunotherapeutic agents (Part 2) in participants with histologically or cytologically confirmed solid tumors that are advanced (i.e., either metastatic or recurrent tumors with no further definitive treatment possible) and/or have relapsed/progressed after prior therapy.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

  • Advanced Solid Tumor

Eligibility basics and study details

Study type
Interventional
Phase
Phase 1/2
Ages
18 years and older
Sex
All
Healthy volunteers
Not accepted
Sponsor
BioNTech SE
Last updated on ClinicalTrials.gov
October 9, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites

Connecticut · 2

  • Hartford Healthcare · Hartford, CT
  • Yale University · New Haven, CT

Florida · 2

  • Florida Cancer Specialists · Sarasota, FL
  • Moffitt Cancer Center · Tampa, FL

Massachusetts · 1

  • Massachusetts General Hospital · Boston, MA

Michigan · 2

  • Brigitte Harris Cancer Pavilion BHCP · Detroit, MI
  • START Midwest, LLC · Grand Rapids, MI

New York · 1

  • Memorial Sloan Kettering Hospital · New York, NY

Ohio · 1

  • Cleveland Clinic Taussig Cancer Center · Cleveland, OH

Pennsylvania · 1

  • University of Pittsburgh Medical Center · Pittsburgh, PA

Texas · 2

  • The University of Texas MD Anderson Cancer Center · Houston, TX
  • South Texas Accelerated Research Therapeutics (START), LLC · San Antonio, TX

Utah · 1

  • START Mountain Region · West Valley City, UT

Wisconsin · 1

  • The Board of Regents of the University of Wisconsin · Madison, WI

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.