Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma
NCT07068074
This study is recruiting at 176 US sites in 36 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of wide local excision (WLE) alone to usual care with WLE plus sentinel lymph node (SLN) biopsy for the treatment of older adults with early-stage melanoma. A WLE is a surgical procedure performed to cut out an abnormal lesion and some surrounding normal tissue. This is sometimes followed by a SLN biopsy, in which lymph nodes that tumor cells could spread to are removed as well. Using WLE alone may be just as effective as usual care in treating older adults with early-stage melanoma.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Cutaneous Melanoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 75 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- ECOG-ACRIN Cancer Research Group
- Last updated on ClinicalTrials.gov
- September 24, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 5
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
- Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis · Daphne, AL
- Thomas Hospital · Fairhope, AL
- Mobile Infirmary Medical Center · Mobile, AL
- Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland · Saraland, AL
Alaska · 1
- Fairbanks Memorial Hospital · Fairbanks, AK
Arizona · 1
- Cancer Center at Saint Joseph's · Phoenix, AZ
California · 17
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Veterans Affairs Loma Linda Healthcare System · Loma Linda, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Mercy Cancer Center · Merced, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Saint Joseph's Medical Center · Stockton, CA
- Woodland Memorial Hospital · Woodland, CA
Colorado · 10
- UCHealth University of Colorado Hospital · Aurora, CO
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- CommonSpirit Cancer Center Mercy · Durango, CO
- Mercy Medical Center · Durango, CO
- CommonSpirit Saint Anthony Hospital Cancer Center · Lakewood, CO
- Longmont United Hospital · Longmont, CO
- Saint Mary Corwin Medical Center · Pueblo, CO
- Saint Anthony North Hospital · Westminster, CO
Delaware · 7
- Beebe Medical Center · Lewes, DE
- Beebe South Coastal Health Campus · Millville, DE
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
- Christiana Care Health System-Wilmington Hospital · Wilmington, DE
Florida · 4
- Orlando Health Cancer Institute - Lake Mary · Lake Mary, FL
- Lakeland Regional Health Hollis Cancer Center · Lakeland, FL
- Health Central · Ocoee, FL
- Orlando Health Cancer Institute · Orlando, FL
Georgia · 2
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
Idaho · 3
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 11
- Loyola Center for Health at Burr Ridge · Burr Ridge, IL
- Northwestern University · Chicago, IL
- Swedish Covenant Hospital · Chicago, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- NorthShore University HealthSystem-Highland Park Hospital · Highland Park, IL
- Loyola Medicine Homer Glen · Homer Glen, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Loyola University Medical Center · Maywood, IL
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb · Melrose Park, IL
- Northwestern Medicine Orland Park · Orland Park, IL
Kansas · 4
- University of Kansas Cancer Center · Kansas City, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- University of Kansas Hospital-Indian Creek Campus · Overland Park, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Kentucky · 8
- CommonSpirit Saint Joseph Hospital - Bardstown · Bardstown, KY
- Commonwealth Cancer Center-Corbin · Corbin, KY
- CommonSpirit Saint Joseph Hospital - Lexington · Lexington, KY
- CommonSpirit Saint Joseph Medical Center - East Lexington · Lexington, KY
- Saint Joseph Radiation Oncology Resource Center · Lexington, KY
- University of Kentucky/Markey Cancer Center · Lexington, KY
- CommonSpirit Saint Joseph Hospital London · London, KY
- CommonSpirit Saint Joseph Hospital Mount Sterling · Mount Sterling, KY
Louisiana · 2
- LSU Health Baton Rouge-North Clinic · Baton Rouge, LA
- Our Lady of the Lake Physician Group · Baton Rouge, LA
Maryland · 1
- Christiana Care - Union Hospital · Elkton, MD
Michigan · 11
- Bronson Battle Creek · Battle Creek, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital · Grand Rapids, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Corewell Health Reed City Hospital · Reed City, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital · Saint Joseph, MI
- Munson Medical Center · Traverse City, MI
- University of Michigan Health - West · Wyoming, MI
Minnesota · 2
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Sanford Thief River Falls Medical Center · Thief River Falls, MN
Missouri · 3
- University of Kansas Cancer Center - Briarcliff · Kansas City, MO
- University of Kansas Cancer Center - North · Kansas City, MO
- University of Kansas Cancer Center - Lee's Summit · Lee's Summit, MO
Montana · 9
- Community Hospital of Anaconda · Anaconda, MT
- Billings Clinic Cancer Center · Billings, MT
- Bozeman Health Deaconess Hospital · Bozeman, MT
- Benefis Sletten Cancer Institute · Great Falls, MT
- Great Falls Clinic · Great Falls, MT
- Hi-Line Sletten Cancer Center · Havre, MT
- Benefis Helena Specialty Center · Helena, MT
- Logan Health Medical Center · Kalispell, MT
- Community Medical Center · Missoula, MT
Nebraska · 5
- CHI Health Saint Francis · Grand Island, NE
- CHI Health Good Samaritan · Kearney, NE
- Alegent Health Bergan Mercy Medical Center · Omaha, NE
- Alegent Health Immanuel Medical Center · Omaha, NE
- Alegent Health Lakeside Hospital · Omaha, NE
Nevada · 1
- Renown Regional Medical Center · Reno, NV
New Jersey · 10
- Hackensack University Medical Center · Hackensack, NJ
- Hackettstown Medical Center · Hackettstown, NJ
- Monmouth Medical Center · Long Branch, NJ
- Morristown Medical Center · Morristown, NJ
- Rutgers Cancer Institute of New Jersey · New Brunswick, NJ
- Newton Medical Center · Newton, NJ
- John Theurer Cancer Center at From Road · Paramus, NJ
- Chilton Medical Center · Pompton, NJ
- Overlook Hospital · Summit, NJ
- Community Medical Center · Toms River, NJ
New Mexico · 2
- Lovelace Women's Hospital · Albuquerque, NM
- University of New Mexico Cancer Center · Albuquerque, NM
New York · 7
- Roswell Park Cancer Institute · Buffalo, NY
- Glens Falls Hospital · Glens Falls, NY
- NYU Langone Hospital - Long Island · Mineola, NY
- Laura and Isaac Perlmutter Cancer Center at NYU Langone · New York, NY
- NYU Langone Hospital - Suffolk · Patchogue, NY
- Stony Brook University Medical Center · Stony Brook, NY
- Montefiore Medical Center-Einstein Campus · The Bronx, NY
North Carolina · 3
- Duke Cancer Center Cary · Cary, NC
- Duke University Medical Center · Durham, NC
- Duke Cancer Center Raleigh · Raleigh, NC
North Dakota · 6
- Sanford Bismarck Medical Center · Bismarck, ND
- Sanford Broadway Medical Center · Fargo, ND
- Sanford Medical Center Fargo · Fargo, ND
- Sanford Roger Maris Cancer Center · Fargo, ND
- Sanford South University Medical Center · Fargo, ND
- Southpointe-Sanford Medical Center Fargo · Fargo, ND
Ohio · 8
- UH Seidman Cancer Center at UH Avon Health Center · Avon, OH
- UHHS-Chagrin Highlands Medical Center · Beachwood, OH
- Bethesda North Hospital · Cincinnati, OH
- Good Samaritan Hospital - Cincinnati · Cincinnati, OH
- TriHealth Cancer Institute-Anderson · Cincinnati, OH
- TriHealth Cancer Institute-Westside · Cincinnati, OH
- Case Western Reserve University · Cleveland, OH
- Ohio State University Comprehensive Cancer Center · Columbus, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Pennsylvania · 6
- Christiana Care Health System-Concord Health Center · Chadds Ford, PA
- Fox Chase Cancer Center - East Norriton Hospital Outpatient Center · East Norriton, PA
- UPMC Hillman Cancer Center Erie · Erie, PA
- Fox Chase Cancer Center · Philadelphia, PA
- Thomas Jefferson University Hospital · Philadelphia, PA
- UPMC Hillman Cancer Center · Pittsburgh, PA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.