A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
NCT07063745
This study is recruiting at 20 US sites in 16 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to compare the clinical benefit of the combination of Navlimetostat (BMS-986504) (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with homozygous MTAP deletion
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2/3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Bristol-Myers Squibb
- Last updated on ClinicalTrials.gov
- September 23, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Mayo Clinic in Arizona - Phoenix · Phoenix, AZ
- University of Arizona Cancer Center · Tucson, AZ
Arkansas · 1
- Highlands Oncology Group · Springdale, AR
California · 1
- USC/Norris Comprehensive Cancer Center · Los Angeles, CA
Florida · 2
- Helios Clinical Research - Fort Lauderdale · Fort Lauderdale, FL
- Mayo Clinic in Florida · Jacksonville, FL
Idaho · 1
- St. Luke's Cancer Institute: Boise · Boise, ID
Kentucky · 2
- Baptist Health Lexington · Lexington, KY
- University of Kentucky Chandler Medical Center · Lexington, KY
Massachusetts · 1
- Dana-Farber Cancer Institute · Boston, MA
Minnesota · 1
- Mayo Clinic in Rochester, Minnesota · Rochester, MN
Nebraska · 1
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists · Omaha, NE
New York · 1
- WMCHealth Advanced Physician Services · Hawthorne, NY
Ohio · 1
- The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center · Columbus, OH
Oregon · 2
- Kaiser Permanente Interstate Medical Office Central · Portland, OR
- Providence Portland Medical Center · Portland, OR
Texas · 1
- University of Texas MD Anderson Cancer Center · Houston, TX
Utah · 1
- Huntsman Cancer Institute · Salt Lake City, UT
Virginia · 1
- Virginia Commonwealth University · Richmond, VA
Washington · 1
- Fred Hutchinson Cancer Center · Seattle, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.