Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial
NCT07061964
This study is recruiting at 171 US sites in 35 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial tests the effect of giving pembrolizumab in combination with radiation therapy after chemotherapy in preventing surgery to remove the bladder in patients with muscle invasive bladder cancer. Standard of care therapy includes chemotherapy before surgery (neoadjuvant) to shrink or get rid of the tumor. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Muscle Invasive Bladder Urothelial Carcinoma
- Stage II Bladder Cancer AJCC v8
- Stage IIIA Bladder Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 1, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
Arizona · 2
- Banner MD Anderson Cancer Center · Gilbert, AZ
- Mayo Clinic Hospital in Arizona · Phoenix, AZ
Arkansas · 3
- Highlands Oncology Group - Fayetteville · Fayetteville, AR
- Highlands Oncology Group - Rogers · Rogers, AR
- Highlands Oncology Group · Springdale, AR
California · 12
- Tower Cancer Research Foundation · Beverly Hills, CA
- City of Hope Corona · Corona, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- City of Hope at Irvine Lennar · Irvine, CA
- City of Hope Antelope Valley · Lancaster, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- City of Hope South Pasadena · South Pasadena, CA
- Cedars-Sinai Cancer - Tarzana · Tarzana, CA
- City of Hope Upland · Upland, CA
Colorado · 9
- UCHealth University of Colorado Hospital · Aurora, CO
- UCHealth - Cherry Creek · Denver, CO
- Shaw Cancer Center · Edwards, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- UCHealth Highlands Ranch Hospital · Highlands Ranch, CO
- UCHealth Lone Tree Health Center · Lone Tree, CO
- Medical Center of the Rockies · Loveland, CO
Connecticut · 11
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Florida · 6
- Mayo Clinic in Florida · Jacksonville, FL
- Moffitt Cancer Center at SouthShore · Ruskin, FL
- Moffitt Cancer Center · Tampa, FL
- Moffitt Cancer Center - McKinley Campus · Tampa, FL
- Moffitt Cancer Center-International Plaza · Tampa, FL
- Moffitt Cancer Center at Wesley Chapel · Wesley Chapel, FL
Georgia · 1
- CTCA at Southeastern Regional Medical Center · Newnan, GA
Illinois · 41
- Rush-Copley Medical Center · Aurora, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- OSF Saint Joseph Medical Center · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Northwestern Medicine Cancer Center Old Irving Park · Chicago, IL
- Northwestern University · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Carle Physician Group-Effingham · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- NorthShore University HealthSystem-Highland Park Hospital · Highland Park, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- OSF Saint Francis Medical Center · Peoria, IL
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
Iowa · 11
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- The Iowa Clinic PC · West Des Moines, IA
Kentucky · 3
- University of Kentucky/Markey Cancer Center · Lexington, KY
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Louisiana · 2
- Ochsner Medical Center Jefferson · New Orleans, LA
- University Medical Center New Orleans · New Orleans, LA
Massachusetts · 3
- Dana-Farber Cancer Institute · Boston, MA
- Tufts Medical Center · Boston, MA
- UMass Memorial Medical Center - University Campus · Worcester, MA
Minnesota · 4
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Fairview Southdale Hospital · Edina, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
Mississippi · 1
- University of Mississippi Medical Center · Jackson, MS
Missouri · 1
- Saint Francis Medical Center · Cape Girardeau, MO
Montana · 2
- Billings Clinic Cancer Center · Billings, MT
- Benefis Sletten Cancer Institute · Great Falls, MT
New Hampshire · 1
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH
New Jersey · 8
- Jefferson Cherry Hill Hospital · Cherry Hill, NJ
- Hunterdon Medical Center · Flemington, NJ
- Jersey City Medical Center · Jersey City, NJ
- Cooperman Barnabas Medical Center · Livingston, NJ
- Monmouth Medical Center · Long Branch, NJ
- Rutgers Cancer Institute of New Jersey · New Brunswick, NJ
- Sidney Kimmel Cancer Center Washington Township · Sewell, NJ
- Community Medical Center · Toms River, NJ
New York · 3
- The New York Hospital Medical Center of Queens · Flushing, NY
- NYP/Weill Cornell Medical Center · New York, NY
- Stony Brook University Medical Center · Stony Brook, NY
North Dakota · 2
- Sanford Broadway Medical Center · Fargo, ND
- Sanford Roger Maris Cancer Center · Fargo, ND
Ohio · 4
- University of Cincinnati Cancer Center-UC Medical Center · Cincinnati, OH
- MetroHealth Medical Center · Cleveland, OH
- Ohio State University Comprehensive Cancer Center · Columbus, OH
- University of Cincinnati Cancer Center-West Chester · West Chester, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Pennsylvania · 3
- Thomas Jefferson University Hospital · Philadelphia, PA
- University of Pennsylvania/Abramson Cancer Center · Philadelphia, PA
- Asplundh Cancer Pavilion · Willow Grove, PA
Rhode Island · 1
- Smilow Cancer Hospital Care Center - Westerly · Westerly, RI
South Dakota · 2
- Sanford Cancer Center Oncology Clinic · Sioux Falls, SD
- Sanford USD Medical Center - Sioux Falls · Sioux Falls, SD
Tennessee · 1
- The West Clinic - Wolf River · Germantown, TN
Texas · 8
- Parkland Memorial Hospital · Dallas, TX
- UT Southwestern Simmons Cancer Center - RedBird · Dallas, TX
- UT Southwestern/Simmons Cancer Center-Dallas · Dallas, TX
- UT Southwestern/Simmons Cancer Center-Fort Worth · Fort Worth, TX
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center · Houston, TX
- UT Southwestern Clinical Center at Richardson/Plano · Richardson, TX
- University of Texas Health Science Center at San Antonio · San Antonio, TX
- Scott and White Memorial Hospital · Temple, TX
Utah · 1
- Huntsman Cancer Institute/University of Utah · Salt Lake City, UT
Vermont · 1
- Dartmouth Cancer Center - North · Saint Johnsbury, VT
Virginia · 1
- VCU Massey Cancer Center at Stony Point · Richmond, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.