A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
NCT06989437
This study is recruiting at 84 US sites in 24 states, according to its ClinicalTrials.gov record last updated .
Summary
Study to investigate the efficacy, safety and tolerability of systemic chemotherapy plus ponsegromab versus systemic chemotherapy plus placebo for the first-line treatment in adult participants with cachexia and metastatic pancreatic ductal adenocardinoma.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Cachexia
- Metastatic Pancreatic Ductal Adenocarcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2/3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Pfizer
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 2
- The Kirklin Clinic of UAB Hospital · Birmingham, AL
- The University of Alabama at Birmingham · Birmingham, AL
Arizona · 1
- Mayo Clinic Hospital · Phoenix, AZ
Arkansas · 5
- Central Arkansas Radiation Therapy Institute, dba CARTI · Bryant, AR
- Central Arkansas Radiation Therapy Institute, dba CARTI · Conway, AR
- CARTI Cancer Center · Little Rock, AR
- Central Arkansas Radiation Therapy Institute, dba CARTI · North Little Rock, AR
- Central Arkansas Radiation Therapy Institute, dba CARTI · Pine Bluff, AR
California · 17
- UC San Diego Medical Center - Encinitas · Encinitas, CA
- Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UCI Health - Irvine · Irvine, CA
- UC San Diego Koman Family Outpatient Pavilion · La Jolla, CA
- UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) · La Jolla, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- UC San Diego Sulpizio Cardiovascular Center · La Jolla, CA
- Cedars-Sinai Cancer at Cedars-Sinai Medical Center · Los Angeles, CA
- UCLA Department of Medicine - Hematology/Oncology · Los Angeles, CA
- UC Irvine Health · Orange, CA
- UC San Diego McGrath Outpatient Pavilion - Hillcrest · San Diego, CA
- UC San Diego Medical Center - Bankers Hill · San Diego, CA
- UC San Diego Medical Center - Hillcrest · San Diego, CA
- UC San Diego Medical Center - Rancho Bernardo · San Diego, CA
- UCLA Hematology/Oncology - Santa Monica · Santa Monica, CA
- Providence Medical Foundation · Santa Rosa, CA
- UC San Diego Medical Center - Vista · Vista, CA
District of Columbia · 2
- Georgetown University Medical Center · Washington D.C., DC
- Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy · Washington D.C., DC
Florida · 2
- Mayo Clinic · Jacksonville, FL
- Mayo Clinic Pharmacy · Jacksonville, FL
Georgia · 1
- University Cancer & Blood Center, LLC · Athens, GA
Hawaii · 3
- Cardiology Associates, Inc · ‘Aiea, HI
- Invision, LLC · Honolulu, HI
- University of Hawaii Cancer Center · Honolulu, HI
Illinois · 5
- Cancer Care Specialists of Illinois · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Hope and Healing Clinical Research LLC · Hinsdale, IL
- Hope and Healing Clinical Research LLC New Lenox- Research Department · New Lenox, IL
- Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon · O'Fallon, IL
Kansas · 2
- United Imaging Consultants · Lenexa, KS
- MidAmerica Cancer Care- American Oncology Partners · Merriam, KS
Kentucky · 4
- University of Kentucky Healthcare - Markey Cancer Center · Lexington, KY
- University of Kentucky Medical Center · Lexington, KY
- University of Kentucky Research Foundation · Lexington, KY
- University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO) · Lexington, KY
Maryland · 4
- JHU Oncology Central Kit Services · Baltimore, MD
- Johns Hopkins Hospital · Baltimore, MD
- Oncology Investigational Drug Service (IDS) · Baltimore, MD
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, MD
Minnesota · 2
- Mayo Clinic · Rochester, MN
- Mayo Clinic Cancer Center Outpatient Pharmacy · Rochester, MN
Missouri · 3
- MidAmerica Cancer Care - American Oncology Partners · Kansas City, MO
- Premier Imaging · Kansas City, MO
- St. Joseph Medical Center · Kansas City, MO
Nebraska · 3
- Nebraska Medicine · Omaha, NE
- Nebraska Medicine - Village Pointe · Omaha, NE
- University of Nebraska Medical Center · Omaha, NE
Nevada · 3
- Renown Health Medical Oncology · Reno, NV
- Renown Office of Clinical Research · Reno, NV
- Renown Regional Medical Center · Reno, NV
New Jersey · 6
- Atlantic Health System / Morristown Medical Center · Morristown, NJ
- Jack & Sheryl Morris Cancer Center · New Brunswick, NJ
- Rutgers Cancer Institute · New Brunswick, NJ
- Rwj University Hospital Somerset · Somerville, NJ
- RWJ University Hospital Somerset, Steeplechase Cancer Center · Somerville, NJ
- Atlantic Health System / Overlook Medical Center · Summit, NJ
New York · 2
- Icahn School of Medicine at Mount Sinai · New York, NY
- University of Rochester Medical Center · Rochester, NY
North Carolina · 3
- UNC Hospitals, The University of North Carolina at Chapel Hill · Chapel Hill, NC
- Levine Cancer Institute · Charlotte, NC
- University of North Carolina Hospitals at Hillsborough · Hillsborough, NC
Oregon · 3
- OHSU Center for Health & Healing 1 · Portland, OR
- Oregon Health and Science University · Portland, OR
- OSHU Center for Health and Healing 2 · Portland, OR
Tennessee · 1
- Henry-Joyce Cancer Clinic · Nashville, TN
Texas · 6
- University of Texas Southwestern Medical Center · Dallas, TX
- University of Texas Southwestern Medical Center - Simmons Cancer Center · Dallas, TX
- University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital · Dallas, TX
- University of Texas Southwestern Medical Center-Zale Lipshy University Hospital · Dallas, TX
- Houston Methodist Hospital · Houston, TX
- Baylor Scott & White Vasicek Cancer Treatment Center · Temple, TX
Washington · 3
- Fred Hutchinson Cancer Center · Seattle, WA
- University of Washington Medical Center · Seattle, WA
- Virginia Mason Medical Center · Seattle, WA
Wisconsin · 1
- Froedtert Hospital and the Medical College of Wisconsin · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.