A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT06973187
This study is recruiting at 48 US sites in 24 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to evaluate the efficacy and safety of tacabrutideg alone compared with pirtobrutinib in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had been previously treated with a covalent Bruton tyrosine kinase inhibitor (cBTKi).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Chronic Lymphocytic Leukemia
- Small Lymphocytic Lymphoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- BeOne Medicines
- Last updated on ClinicalTrials.gov
- September 28, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama At Birmingham Hospital · Birmingham, AL
Arizona · 1
- Mayo Clinic Phoenix · Phoenix, AZ
California · 11
- Kaiser Permanente Southern California · Irvine, CA
- University of California San Diego (Ucsd) Moores Cancer Center · La Jolla, CA
- Cancer and Blood Specialty Clinic · Los Alamitos, CA
- UCLA Department of Medicine Hematologyoncology · Los Angeles, CA
- Kaiser Permanente Oakland Medical Center · Oakland, CA
- Stanford Cancer Institute · Palo Alto, CA
- Kaiser Permanente Roseville Medical Center · Roseville, CA
- Kaiser Permanente San Francisco Medical Center Oncology · San Francisco, CA
- Kaiser Permanente Santa Clara Medical Center Oncologyhematology · Santa Clara, CA
- Kaiser Permanente Northern California · Vallejo, CA
- Kaiser Permanente Walnut Creek Medical Center · Walnut Creek, CA
Delaware · 1
- Christiana Care · Newark, DE
District of Columbia · 1
- Medstar Georgetown University Hospital · Washington D.C., DC
Florida · 3
- Cancer Specialists of North Florida · Jacksonville, FL
- Mayo Clinic Jacksonville · Jacksonville, FL
- Mount Sinai Medical Center Braman Comprehensive Cancer Center · Miami, FL
Illinois · 1
- University of Chicago Medical Center · Chicago, IL
Iowa · 1
- Mission Cancer and Blood · Waukee, IA
Kansas · 1
- The University of Kansas Cancer Center · Westwood, KS
Louisiana · 3
- Mary Bird Perkins Cancer Center · Baton Rouge, LA
- Our Lady of the Lake Hospital · Baton Rouge, LA
- Ochsner Clinic Foundation · New Orleans, LA
Massachusetts · 1
- Dana Farber Cancer Institute · Boston, MA
Michigan · 1
- Karmanos Cancer Institute · Detroit, MI
Minnesota · 1
- Mayo Clinic Rochester · Rochester, MN
Missouri · 1
- Washington University School of Medicine · St Louis, MO
New Jersey · 2
- Titan Health Partners Llc Dba Astera Cancer Care · East Brunswick, NJ
- John Theurer Cancer Center Hackensack University Medical Center · Hackensack, NJ
New York · 4
- Columbia University Medical Center · New York, NY
- Memorial Sloan Kettering Cancer Center Mskcc · New York, NY
- Weill Cornell Medical College Newyork Presbyterian Hospital · New York, NY
- University of Rochester · Rochester, NY
North Carolina · 4
- University of North Carolina At Chapel Hill · Chapel Hill, NC
- Atrium Health Levine Cancer Institute (Lci) · Charlotte, NC
- Duke University Medical Center · Durham, NC
- Atrium Health Wake Forest Baptist · Winston-Salem, NC
Ohio · 1
- Dayton Physician Network · Dayton, OH
Pennsylvania · 1
- Fox Chase Cancer Center · Philadelphia, PA
South Carolina · 1
- Medical University of South Carolina · Charleston, SC
Tennessee · 1
- Tennessee Oncology, Pllc Nashville · Nashville, TN
Texas · 2
- Md Anderson Cancer Center · Houston, TX
- Texas Oncology Palestine Cancer Center · Palestine, TX
Washington · 3
- Fred Hutchinson Cancer Research Center · Seattle, WA
- Summit Cancer Centers · Spokane, WA
- Northwest Medical Specialties · Tacoma, WA
Wisconsin · 1
- Gunderson Health System · La Crosse, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.