Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer
NCT06958328
This study is recruiting at 324 US sites in 42 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of dose-escalated radiation therapy to usual care in patients with locally advanced unresectable pancreatic ductal adenocarcinoma who have received an initial 4-8 months of chemotherapy. Usual care options include additional chemotherapy, observation, or standard lower-dose radiation therapy. These treatments may delay tumor growth but have not been shown to improve survival. Radiation therapy uses high energy X-rays to kill cancer cells and shrink tumors.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma
- Stage II Pancreatic Cancer AJCC v8
- Stage III Pancreatic Cancer AJCC v8
- Stage IV Pancreatic Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- NRG Oncology
- Last updated on ClinicalTrials.gov
- August 25, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 8
- Arizona Center for Cancer Care - Gilbert · Gilbert, AZ
- Banner MD Anderson Cancer Center · Gilbert, AZ
- Arizona Center for Cancer Care-Peoria · Peoria, AZ
- Arizona Center for Cancer Care - Phoenix · Phoenix, AZ
- Banner-University Medical Center Phoenix · Phoenix, AZ
- Arizona Center for Cancer Care - Scottsdale · Scottsdale, AZ
- Arizona Center for Cancer Care-Surprise · Surprise, AZ
- Arizona Center for Cancer Care · Tempe, AZ
Arkansas · 1
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro · Jonesboro, AR
California · 23
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- AIS Cancer Center at San Joaquin Community Hospital · Bakersfield, CA
- Alta Bates Summit Medical Center-Herrick Campus · Berkeley, CA
- Mills-Peninsula Medical Center · Burlingame, CA
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park · Cameron Park, CA
- Palo Alto Medical Foundation-Fremont · Fremont, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Memorial Medical Center · Modesto, CA
- Palo Alto Medical Foundation-Camino Division · Mountain View, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Palo Alto Medical Foundation Health Care · Palo Alto, CA
- Stanford Cancer Institute Palo Alto · Palo Alto, CA
- Sutter Cancer Centers Radiation Oncology Services-Roseville · Roseville, CA
- Sutter Roseville Medical Center · Roseville, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- California Pacific Medical Center-Pacific Campus · San Francisco, CA
- Mills Health Center · San Mateo, CA
- Ridley-Tree Cancer Center · Santa Barbara, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Sutter Pacific Medical Foundation · Santa Rosa, CA
- Palo Alto Medical Foundation-Sunnyvale · Sunnyvale, CA
- Sutter Solano Medical Center/Cancer Center · Vallejo, CA
Colorado · 6
- Memorial Hospital North · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- AdventHealth Porter · Denver, CO
- AdventHealth Littleton · Littleton, CO
- AdventHealth Parker · Parker, CO
Connecticut · 16
- Danbury Hospital · Danbury, CT
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital-Hamden Care Center · Hamden, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Smilow Cancer Center/Yale-New Haven Hospital · New Haven, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Norwalk Hospital · Norwalk, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 4
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Christiana Care Health System-Wilmington Hospital · Wilmington, DE
District of Columbia · 1
- MedStar Washington Hospital Center · Washington D.C., DC
Florida · 5
- Morton Plant Hospital · Clearwater, FL
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- Miami Cancer Institute · Miami, FL
- AdventHealth Orlando · Orlando, FL
- Saint Joseph's Hospital/Children's Hospital-Tampa · Tampa, FL
Georgia · 6
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
- Piedmont Hospital · Atlanta, GA
- Memorial Health University Medical Center · Savannah, GA
Hawaii · 13
- Hawaii Cancer Care - Westridge · ‘Aiea, HI
- Pali Momi Medical Center · ‘Aiea, HI
- Queen's Cancer Center - Pearlridge · ‘Aiea, HI
- The Queen's Medical Center - West Oahu · ‘Ewa Beach, HI
- Hawaii Cancer Care Inc - Waterfront Plaza · Honolulu, HI
- Kapiolani Medical Center for Women and Children · Honolulu, HI
- Kuakini Medical Center · Honolulu, HI
- Queen's Cancer Cenrer - POB I · Honolulu, HI
- Queen's Cancer Center - Kuakini · Honolulu, HI
- Queen's Medical Center · Honolulu, HI
- Straub Clinic and Hospital · Honolulu, HI
- University of Hawaii Cancer Center · Honolulu, HI
- Wilcox Memorial Hospital and Kauai Medical Clinic · Lihue, HI
Illinois · 48
- Advocate Outpatient Center - Aurora · Aurora, IL
- Rush-Copley Medical Center · Aurora, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Northwestern University · Chicago, IL
- University of Illinois · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate High Tech Medical Park · Palos Heights, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- OSF Saint Francis Medical Center · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 8
- Northwest Cancer Center - Crown Point · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Goshen Center for Cancer Care · Goshen, IN
- Northwest Cancer Center - Hobart · Hobart, IN
- Saint Mary Medical Center · Hobart, IN
- The Community Hospital · Munster, IN
- Women's Diagnostic Center - Munster · Munster, IN
- Northwest Cancer Center - Valparaiso · Valparaiso, IN
Iowa · 6
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Iowa Methodist Medical Center · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kansas · 5
- University of Kansas Cancer Center · Kansas City, KS
- Lawrence Memorial Hospital · Lawrence, KS
- The University of Kansas Cancer Center - Olathe · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- Salina Regional Health Center · Salina, KS
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.