A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer
NCT06892548
This study is recruiting at 17 US sites in 11 states, according to its ClinicalTrials.gov record last updated .
Summary
This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate (ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial growth factor (VEGF) bispecific antibody, in participants with advanced/metastatic or relapsed/progressive small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Advanced Lung Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1/2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- BioNTech SE
- Last updated on ClinicalTrials.gov
- August 26, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Mayo Clinic Arizona · Phoenix, AZ
California · 3
- Precision NextGen Oncology and Research Center · Beverly Hills, CA
- Cedars Sinai Medical Center · Los Angeles, CA
- UCLA - David Geffen School of Medicine · Santa Monica, CA
Colorado · 1
- University of Colorado Cancer Center · Aurora, CO
Florida · 1
- Mayo Clinic in Florida · Jacksonville, FL
Iowa · 1
- University of Iowa Hospitals & Clinics PARENT · Iowa City, IA
Minnesota · 1
- Mayo Clinic-Rochester · Rochester, MN
New Jersey · 2
- Regional Cancer Care Associates · Belleville, NJ
- John Theurer Cancer Center at Hackensack UMC · Hackensack, NJ
New York · 2
- Icahn School of Medicine at Mount Sinai PRIME · New York, NY
- Memorial Sloan Kettering Cancer Center (MSKCC) · New York, NY
Ohio · 1
- Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center · Cleveland, OH
Texas · 3
- Texas Oncology - DFW · Dallas, TX
- MD Anderson Cancer Center · Houston, TX
- Texas Oncology - Northeast · Tyler, TX
Virginia · 1
- Virginia Cancer Specialists · Fairfax, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.