A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
NCT06875310
This study is recruiting at 42 US sites in 21 states, according to its ClinicalTrials.gov record last updated .
Summary
This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Carcinoma, Non-Small-Cell Lung
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Mirati Therapeutics Inc.
- Last updated on ClinicalTrials.gov
- October 13, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham · Birmingham, AL
Arkansas · 1
- Highlands Oncology Group - Springdale · Springdale, AR
California · 2
- Providence Medical Foundation · Fullerton, CA
- Helios Clinical Research · Long Beach, CA
Colorado · 1
- National Jewish Health Medical Center · Denver, CO
Delaware · 1
- Medical Oncology Hematology Consultants, PA · Newark, DE
Florida · 9
- Morton Plant Hospital - BayCare Health System · Clearwater, FL
- Cancer Specialists of North Florida · Jacksonville, FL
- Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala · Ocala, FL
- Mid Florida Hematology and Oncology Center · Orange City, FL
- Cancer Care Centers of Brevard, Inc. · Palm Bay, FL
- Florida Clinical Trials Group. · Plantation, FL
- St. Anthony's Hospital · St. Petersburg, FL
- Florida Clinical Trials Group. · Tamarac, FL
- H. Lee Moffitt Cancer Center & Research Institute · Tampa, FL
Georgia · 1
- Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital · Marietta, GA
Illinois · 3
- Illinois Cancer Specialists · Arlington Heights, IL
- University of Illinois at Chicago · Chicago, IL
- Springfield Clinic Main Campus · Springfield, IL
Indiana · 2
- Northwest Cancer Centers, P.C. · Dyer, IN
- Parkview Research Center at Parkview Regional Medical Center · Fort Wayne, IN
Iowa · 1
- Mercy Medical Center · Cedar Rapids, IA
Kentucky · 4
- Saint Elizabeth Medical Center Edgewood · Edgewood, KY
- The University of Louisville, James Graham Brown Cancer Center · Louisville, KY
- Owensboro Medical Health System · Owensboro, KY
- Mercy Health-Paducah Medical Oncology and Hematology · Paducah, KY
Louisiana · 1
- Louisiana State University Health Sciences Shreveport · Shreveport, LA
Maryland · 2
- Velocity Clinical Research, Annapolis · Annapolis, MD
- Maryland Oncology Hematology - Columbia · Columbia, MD
Massachusetts · 1
- Dana-Farber Cancer Institute · Boston, MA
Michigan · 1
- Karmanos Cancer Institute · Detroit, MI
Missouri · 1
- SSM Health Cancer Care - Fenton · Fenton, MO
New York · 2
- Ellis Hospital · Schenectady, NY
- White Plains Hospital · White Plains, NY
Pennsylvania · 1
- WellSpan Oncology Research · York, PA
South Carolina · 1
- St Francis Cancer Center · Greenville, SC
Tennessee · 1
- SCRI Oncology Partners · Nashville, TN
Texas · 5
- Texas Oncology Sammons Cancer Center · Dallas, TX
- University Of Texas Medical Branch At Galveston · Galveston, TX
- Oncology & Hematology of South Texas · Laredo, TX
- Texas Oncology - San Antonio · San Antonio, TX
- Texas Oncology - Northeast Texas · Tyler, TX
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.