A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
NCT06819878
This study is recruiting at 93 US sites in 26 states, according to its ClinicalTrials.gov record last updated .
Summary
This Phase III, multicenter, double-blind, placebo-controlled treat-through study will evaluate the efficacy and safety of induction and maintenance therapy with Afimkibart (also known as RO7790121) in participants with moderately to severely active Crohn's disease (CD).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Moderately to Severely Active Crohns Disease
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 16 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Hoffmann-La Roche
- Last updated on ClinicalTrials.gov
- September 16, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan · Dothan, AL
Arizona · 3
- Mayo Clinic Hospital · Phoenix, AZ
- Arizona Digestive Health, P.C (ADH) · Sun City, AZ
- University of Arizona-CATS Research Center · Tucson, AZ
California · 10
- Valley View Internal Medicine · Garden Grove, CA
- 310 Clinical Research · Inglewood, CA
- UCSD Medical Center · La Jolla, CA
- University of California San Diego · La Jolla, CA
- Gastro Care Associates · Lancaster, CA
- Om Research LLC · Lancaster, CA
- United Gastroenterologists · Los Alamitos, CA
- Acclaim Clinical Research, Inc. · San Diego, CA
- Kaiser Permanente · San Francisco, CA
- UCSF/Medical Center at Mount Zion · San Francisco, CA
Colorado · 2
- Rocky Mountain Gastroenterology · Littleton, CO
- Peak Gastroenterology Surgery Center · Lone Tree, CO
Florida · 16
- Access Research Institute · Brooksville, FL
- Gastro Florida · Clearwater, FL
- HealthMed Clinical Center Inc. · Coral Gables, FL
- Hi Tech and Global Research, LLC · Coral Gables, FL
- NeoClinical Research · Hialeah, FL
- The Sister Life Research · Hialeah, FL
- Clinical Research of Osceola, LLC · Kissimmee, FL
- Florida Research Institute - Lakewood · Lakewood Rch, FL
- LCC Medical Research Institute, LLC · Miami, FL
- Orlando Regional Healthcare · Orlando, FL
- Guardian Angel Research Center, LLC · Tampa, FL
- Nodal Medical Center Research - NMC · Tampa, FL
- University of South Florida School of Medicine Morsani Center for Advanced Health Care · Tampa, FL
- Theia Clinical Research Centers, LLC · Temple Terrace, FL
- Cleveland Clinic Florida · Weston, FL
- Florida Medical Clinic - Orlando Health · Zephyrhills, FL
Georgia · 3
- Atlanta Gastroenterology Associates · Atlanta, GA
- Digestive Healthcare of Georgia · Atlanta, GA
- Gastroenterology Associates of Central Georgia · Macon, GA
Idaho · 1
- Grand Teton Research Group, PLLC · Idaho Falls, ID
Illinois · 3
- Northwestern Memorial Hospital · Chicago, IL
- Illinois Gastroenterology Group-Glenview powered by GI Alliance · Glenview, IL
- GI Alliance - Gurnee · Gurnee, IL
Indiana · 2
- Indiana University Health University Hospital · Indianapolis, IN
- Gastroenterology Health Partners, PLLC · New Albany, IN
Kansas · 1
- Kansas Gastroenterology, LLC under Clinical Trials Network · Wichita, KS
Kentucky · 2
- Tri-State Gastroenterology Associates · Crestview Hills, KY
- Gastroenterology Health Partners, PLLC · Louisville, KY
Massachusetts · 2
- Boston University · Boston, MA
- Brigham and Women's Hospital · Boston, MA
Michigan · 1
- Michigan Center of Medical Research · Farmington Hills, MI
Mississippi · 2
- Gastroenterology Associates and Endoscopy Center of North Mississippi · Oxford, MS
- Delta Gastroenterology & Endoscopy Center · Southaven, MS
Nevada · 1
- Las Vegas Clinical Trials, LLC · North Las Vegas, NV
New York · 7
- Lenox Hill Hospital · New York, NY
- Mount Sinai Hospital - IBD Clinical Center · New York, NY
- DiGiovanna Inst for Med Ed&Res · North Massapequa, NY
- Queens Village Medical Care · Queens Village, NY
- Mainstreet - Richmond Hill Clinic · Richmond Hill, NY
- Gastroenterology Group Of Rochester, LLP · Rochester, NY
- University of Rochester Medical Center · Rochester, NY
North Carolina · 3
- Atrium Health, Carolinas Healthcare System · Charlotte, NC
- Omega Research North Carolina, LLC · Fuquay-Varina, NC
- Monroe Biomedical Research · Monroe, NC
Ohio · 8
- Dayton Gastroenterology, Inc. · Beavercreek, OH
- Digestive Disease Consultants · Brunswick, OH
- University of Cincinnati Hospital · Cincinnati, OH
- Cleveland Clinic Foundation · Cleveland, OH
- Ohio Gastroenterology Group · Columbus, OH
- The Ohio State University Wexner Medical Center · Columbus, OH
- Gastro Health- Liberty · Liberty Township, OH
- Gastro Intestinal Research Institute of Northern Ohio · Westlake, OH
Oklahoma · 1
- Central Sooner Research · Norman, OK
Pennsylvania · 2
- Penn State Milton S. Hershey Medical Center · Hershey, PA
- Frontier Clinical Re search, LLC · Uniontown, PA
Rhode Island · 1
- University Gastroenterology · Providence, RI
South Carolina · 2
- Medical University of South Carolina · Charleston, SC
- Gastroenterology Associates · Greenville, SC
Tennessee · 2
- Gastro One · Germantown, TN
- Quality Medical Research · Nashville, TN
Texas · 11
- Texas Clinical Research Institute, LLC · Arlington, TX
- Proactive El Paso,LLC · El Paso, TX
- Amel Med LLC · Georgetown, TX
- Cano Medical Center · Harlingen, TX
- Baylor College of Medicine · Houston, TX
- TDDC dba GI Alliance Research · Mansfield, TX
- SMS Clinical Research, LLC · Mesquite, TX
- Gastroenterology Research of America, LLC · San Antonio, TX
- GI Alliance - Southlake · Southlake, TX
- Baylor Scott and White Medical Center · Temple, TX
- Tyler Research Institute, LLC · Tyler, TX
Virginia · 5
- Tidewater Gastroenterology Pllc T/A Gastro. Assoc. of Tidewater · Chesapeake, VA
- Emeritas Research Group · Lansdowne Town Center, VA
- Blue Ridge Medical Research - Gastroenterology Associates of Central Virginia · Lynchburg, VA
- Gastroenterology Consultants and Endoscopy Center of Southwest Virginia · Roanoke, VA
- Tidewater Physicians Multispecialty Group (TPMG) - Clinical Research Division - Williamsburg · Williamsburg, VA
Washington · 1
- The Vancouver Clinic · Vancouver, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.