Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study
NCT06769126
This study is recruiting at 145 US sites in 27 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial tests how well biomarker tests on patients tumor tissue works in selecting personalized treatments for patients with extensive stage small cell lung cancer (ES-SCLC). Biomarker tests look for certain features in cancer cells that may give doctors more information about what is driving cancer and how to treat it. Based on the biomarker test results, study doctors can determine the subtype of ES-SCLC that study treatments can target. This study also tests different types of maintenance treatment for ES-SCLC with drugs durvalumab, saruparib, ceralasertib or monalizumab.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Extensive Stage Lung Small Cell Carcinoma
- Lung Small Cell Carcinoma, A Subtype
- Lung Small Cell Carcinoma, I Subtype
- Lung Small Cell Carcinoma, N Subtype
- Lung Small Cell Carcinoma, P Subtype
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- SWOG Cancer Research Network
- Last updated on ClinicalTrials.gov
- March 30, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 3
- Loma Linda University Medical Center · Loma Linda, CA
- Eisenhower Medical Center · Rancho Mirage, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
Colorado · 8
- UCHealth University of Colorado Hospital · Aurora, CO
- Memorial Hospital North · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- Lutheran Hospital - Cancer Centers of Colorado · Golden, CO
- UCHealth Greeley Hospital · Greeley, CO
- Medical Center of the Rockies · Loveland, CO
Connecticut · 9
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 2
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
Georgia · 1
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler · Savannah, GA
Idaho · 4
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 10
- Northwestern University · Chicago, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Loyola University Medical Center · Maywood, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
Iowa · 14
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- The Iowa Clinic PC · West Des Moines, IA
Kansas · 6
- University of Kansas Clinical Research Center · Fairway, KS
- University of Kansas Cancer Center · Kansas City, KS
- The University of Kansas Cancer Center - Olathe · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- Salina Regional Health Center · Salina, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Kentucky · 3
- Baptist Health Corbin · Corbin, KY
- Baptist Health Hamburg · Lexington, KY
- Baptist Health Lexington · Lexington, KY
Maryland · 1
- University of Maryland/Greenebaum Cancer Center · Baltimore, MD
Massachusetts · 3
- Tufts Medical Center · Boston, MA
- Lahey Hospital and Medical Center · Burlington, MA
- Lahey Medical Center-Peabody · Peabody, MA
Michigan · 16
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Henry Ford Health Saint John Hospital · Detroit, MI
- Henry Ford Saint John Hospital - Academic · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Breast · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Van Elslander · Grosse Pointe Woods, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Henry Ford Saint John Hospital - Macomb Medical · Macomb, MI
- Henry Ford Warren Hospital - Breast Macomb · Macomb, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Henry Ford Health Warren Hospital · Warren, MI
- Henry Ford Madison Heights Hospital - Breast · Warren, MI
- Henry Ford Warren Hospital - GLCMS · Warren, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 16
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Essentia Health Saint Joseph's Medical Center · Brainerd, MN
- Mercy Hospital · Coon Rapids, MN
- Essentia Health - Deer River Clinic · Deer River, MN
- Essentia Health Cancer Center · Duluth, MN
- Fairview Southdale Hospital · Edina, MN
- Essentia Health Hibbing Clinic · Hibbing, MN
- Saint John's Hospital - Healtheast · Maplewood, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Hennepin County Medical Center · Minneapolis, MN
- New Ulm Medical Center · New Ulm, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Essentia Health Sandstone · Sandstone, MN
- Essentia Health Virginia Clinic · Virginia, MN
Missouri · 5
- University of Kansas Cancer Center - Briarcliff · Kansas City, MO
- University of Kansas Cancer Center - North · Kansas City, MO
- University of Kansas Cancer Center - Lee's Summit · Lee's Summit, MO
- Mercy Hospital Saint Louis · St Louis, MO
- Mercy Hospital South · St Louis, MO
Montana · 5
- Community Hospital of Anaconda · Anaconda, MT
- Billings Clinic Cancer Center · Billings, MT
- Bozeman Health Deaconess Hospital · Bozeman, MT
- Benefis Sletten Cancer Institute · Great Falls, MT
- Community Medical Center · Missoula, MT
New York · 3
- Roswell Park Cancer Institute · Buffalo, NY
- University of Rochester · Rochester, NY
- Wilmot Cancer Institute at Webster · Webster, NY
North Carolina · 1
- FirstHealth of the Carolinas-Moore Regional Hospital · Pinehurst, NC
North Dakota · 4
- Sanford Bismarck Medical Center · Bismarck, ND
- Essentia Health Cancer Center-South University Clinic · Fargo, ND
- Sanford Broadway Medical Center · Fargo, ND
- Sanford Roger Maris Cancer Center · Fargo, ND
Ohio · 8
- Aultman Health Foundation · Canton, OH
- Miami Valley Hospital South · Centerville, OH
- Miami Valley Hospital · Dayton, OH
- Miami Valley Hospital North · Dayton, OH
- Premier Blood and Cancer Center · Dayton, OH
- Atrium Medical Center-Middletown Regional Hospital · Franklin, OH
- Miami Valley Cancer Care and Infusion · Greenville, OH
- Upper Valley Medical Center · Troy, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Oregon · 4
- Providence Newberg Medical Center · Newberg, OR
- Providence Willamette Falls Medical Center · Oregon City, OR
- Providence Portland Medical Center · Portland, OR
- Providence Saint Vincent Medical Center · Portland, OR
South Carolina · 9
- Saint Joseph's/Candler - Bluffton Campus · Bluffton, SC
- Prisma Health Cancer Institute - Spartanburg · Boiling Springs, SC
- Prisma Health Cancer Institute - Easley · Easley, SC
- Tidelands Georgetown Memorial Hospital · Georgetown, SC
- Prisma Health Cancer Institute - Butternut · Greenville, SC
- Prisma Health Cancer Institute - Eastside · Greenville, SC
- Prisma Health Cancer Institute - Faris · Greenville, SC
- Prisma Health Cancer Institute - Greer · Greer, SC
- Prisma Health Cancer Institute - Seneca · Seneca, SC
South Dakota · 2
- Sanford Cancer Center Oncology Clinic · Sioux Falls, SD
- Sanford USD Medical Center - Sioux Falls · Sioux Falls, SD
Texas · 1
- M D Anderson Cancer Center · Houston, TX
Virginia · 4
- VCU Massey Cancer Center at Stony Point · Richmond, VA
- VCU Massey Comprehensive Cancer Center · Richmond, VA
- VCU Community Memorial Health Center · South Hill, VA
- VCU Health Tappahannock Hospital · Tappahannock, VA
Wisconsin · 2
- Duluth Clinic Ashland · Ashland, WI
- Gundersen Lutheran Medical Center · La Crosse, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.