A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
NCT06750094
This study is recruiting at 68 US sites in 26 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus either cetuximab or bevacizumab and FOLFIRI given to participants with Kirsten rat sarcoma viral oncogene/ neuroblastoma RAS viral oncogene homolog (KRAS/ NRAS) and v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type recurrent…
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Colorectal Neoplasms
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Janssen Research & Development, LLC
- Last updated on ClinicalTrials.gov
- September 25, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Ironwood Cancer and Research Center · Chandler, AZ
- Banner MD Anderson Cancer Center · Gilbert, AZ
Arkansas · 2
- St. Bernard's Medical Center · Jonesboro, AR
- Highlands Oncology Group · Springdale, AR
California · 7
- CBCC Global Research · Bakersfield, CA
- Los Angeles Cancer Network · Glendale, CA
- Cancer and Blood Specialty Clinic · Los Alamitos, CA
- USC Norris Comprehensive Cancer Center · Los Angeles, CA
- UCLA · Santa Monica, CA
- Providence Medical Foundation · Santa Rosa, CA
- Torrance Memorial Physicians Network · Torrance, CA
Colorado · 2
- University of Colorado Denver Anschultz Medical Campus · Aurora, CO
- Rocky Mountain Cancer Centers · Denver, CO
Florida · 4
- Florida Cancer Specialists South · Fort Myers, FL
- AdventHealth Cancer Institute · Orlando, FL
- Florida Cancer Specialists North Region · St. Petersburg, FL
- Florida Cancer Specialists East · West Palm Beach, FL
Georgia · 4
- University Cancer And Blood Center LLC · Athens, GA
- Grady Memorial Hospital · Atlanta, GA
- Piedmont Cancer Institute · Atlanta, GA
- Winship Cancer Institute Emory University · Atlanta, GA
Illinois · 2
- Illinois Cancer Specialists · Arlington Heights, IL
- Illinois CancerCare · Peoria, IL
Indiana · 1
- Franciscan Health · Indianapolis, IN
Iowa · 2
- University of Iowa Hospitals and Clinics · Iowa City, IA
- Mission Cancer Blood · Waukee, IA
Kansas · 1
- Cancer Center of Kansas · Wichita, KS
Louisiana · 1
- Mary Bird Perkins Cancer Center · Baton Rouge, LA
Maryland · 2
- MedStar Franklin Square Medical Center · Baltimore, MD
- Frederick Health Hospital - James M Stockman Cancer Institute · Frederick, MD
Michigan · 3
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- Henry Ford Hospital · Detroit, MI
- Cancer And Hematology Centers of Western Michigan PC · Grand Rapids, MI
Mississippi · 1
- Hattiesburg Clinic · Hattiesburg, MS
Missouri · 1
- Washington University School Of Medicine · St Louis, MO
Nebraska · 1
- Nebraska Cancer Specialists · Omaha, NE
New Jersey · 1
- Astera Cancer Care · East Brunswick, NJ
New York · 5
- Perlmutter Cancer Center at NYU Long Island · Mineola, NY
- NYU Langone Medical Center NYU Hematology Associates · New York, NY
- New York Cancer and Blood Specialists · Shirley, NY
- Montefiore Einstein Comprehensive Cancer Center · The Bronx, NY
- University of Buffalo Kaleida Health Cancer Care · Williamsville, NY
Ohio · 2
- Gabrail Cancer Center · Canton, OH
- University Hospital of Cleveland · Cleveland, OH
Oregon · 1
- Oregon Health And Science University · Portland, OR
Pennsylvania · 4
- Alliance Cancer Specialists at Main Line · Penn Wynne, PA
- Fox Chase Cancer Center · Philadelphia, PA
- Thomas Jefferson University · Philadelphia, PA
- University Of Pittsburgh Medical Center UPMC Hillman Cancer Center · Pittsburgh, PA
Tennessee · 4
- Tennessee Oncology Chattanooga · Chattanooga, TN
- SCRI Oncology Partners · Nashville, TN
- Tennessee Oncology · Nashville, TN
- Vanderbilt University Medical Center · Nashville, TN
Texas · 9
- Texas Oncology West Texas · Abilene, TX
- Parkland Health and Hospital System · Dallas, TX
- Texas Oncology DFW · Dallas, TX
- UT Southwestern Medical Center · Dallas, TX
- MD Anderson Cancer Center · Houston, TX
- Baylor Scott & White Medical Center · Round Rock, TX
- Texas Oncology - San Antonio · San Antonio, TX
- Scott And White Memorial Hospital · Temple, TX
- UT Health East Texas HOPE Cancer Center · Tyler, TX
Virginia · 3
- Virginia Cancer Specialists · Arlington, VA
- Richmond VA Medical Center · Richmond, VA
- VCU Massey Comprehensive Cancer Center · Richmond, VA
Washington · 2
- Providence Regional Cancer System · Lacey, WA
- Fred Hutchinson Cancer Research Center · Seattle, WA
Wisconsin · 1
- Medical College Of Wisconsin · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.