Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
NCT06712355
This study is recruiting at 34 US sites in 19 states, according to its ClinicalTrials.gov record last updated .
Summary
This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Extensive-stage Small-cell Lung Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- BioNTech SE
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- ACRC Arizona Clinical Research Center · Tucson, AZ
Florida · 1
- Cancer Care Centers of Brevard, Inc · Palm Bay, FL
Georgia · 1
- Northside Hospital Atlanta · Atlanta, GA
Illinois · 1
- Illinois Cancer Specialists · Niles, IL
Indiana · 1
- Fort Wayne Medical Oncology and Hematology, Inc · Fort Wayne, IN
Iowa · 2
- McFarland Clinic · Ames, IA
- Helen G. Nassif Community Cancer Center · Cedar Rapids, IA
Kentucky · 1
- Baptist Health Hardin Cancer Center · Elizabethtown, KY
Louisiana · 2
- LSU Health Baton Rouge - North Clinic · Baton Rouge, LA
- Our Lady of the Lake Hospital, Inc. · Baton Rouge, LA
Maryland · 1
- Frederick Health Hospital- James M Stockman Cancer Institute · Frederick, MD
Massachusetts · 1
- Beth Israel Lahey Health - Lahey Hospital & Medical Center (LHMC), Lahey Clinic Medical Center · Burlington, MA
Mississippi · 1
- Baptist Cancer Center · Southaven, MS
Missouri · 1
- Washington University School of Medicine · St Louis, MO
Nebraska · 1
- Nebraska Hematology-Oncology (NHO) · Lincoln, NE
New York · 2
- Cornell University - NewYork-Presbyterian/Weill Cornell Medical Center · New York, NY
- White Plains Hospital · White Plains, NY
Ohio · 8
- Cleveland Clinic - Akron General Hematology & Oncology · Akron, OH
- Cleveland Clinic Mercy Hospital Cancer Center · Canton, OH
- The Christ Hospital Cancer Center · Cincinnati, OH
- Cleveland Clinic Foundation · Cleveland, OH
- The Cleveland Clinic Cancer Center at Fairview Hospital, Moll Pavilion · Cleveland, OH
- University Hospitals Cleveland Medical Center · Cleveland, OH
- Kettering Medical Center · Kettering, OH
- Cleveland Clinic - Hillcrest Hospital · Mayfield Heights, OH
Pennsylvania · 1
- St. Luke's Physician Group - St. Luke's Cancer Care Associates · Fountain Hill, PA
Tennessee · 2
- West Cancer Center & Research Institute · Germantown, TN
- University of Tennessee Medical Center · Knoxville, TN
Texas · 2
- The University of Texas MD Anderson Cancer Center · Houston, TX
- Texas Oncology Cancer Center · Sugar Land, TX
Virginia · 4
- Virginia Cancer Specialists · Fairfax, VA
- Hematology Oncology Associates of Fredericksburg, Inc. · Fredericksburg, VA
- Virginia Commonwealth University School of Medicine · Richmond, VA
- Shenandoah Oncology · Winchester, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.