A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT06667076
This study is recruiting at 119 US sites in 32 states, according to its ClinicalTrials.gov record last updated .
Summary
The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC; that is one of the major types of lung cancer).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Carcinoma, Non-Small-Cell Lung
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Janssen Research & Development, LLC
- Last updated on ClinicalTrials.gov
- September 25, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- Southern Cancer Center, PC · Daphne, AL
Arizona · 1
- City of Hope Phoenix · Goodyear, AZ
California · 29
- The Oncology Institute of Hope and Innovation · Cerritos, CA
- City of Hope Corona · Corona, CA
- City of Hope · Duarte, CA
- Providence Medical Foundation · Fullerton, CA
- Glendale Adventist Medical Center · Glendale, CA
- Los Angeles Cancer Network · Glendale, CA
- Marin Cancer Center · Greenbrae, CA
- City of Hope Seacliff · Huntington Beach, CA
- City of Hope Orange County Lennar Foundation Cancer Center · Irvine, CA
- University of California San Diego Health · La Jolla, CA
- City of Hope Antelope Valley · Lancaster, CA
- City of Hope Long Beach Elm · Long Beach, CA
- Cancer and Blood Specialty Clinic · Los Alamitos, CA
- Cedars Sinai Medical Center · Los Angeles, CA
- USC Norris Comprehensive Cancer Center · Los Angeles, CA
- Valkyrie Clinical Trials · Los Angeles, CA
- Valkyrie Clinical Trials Murrieta · Murrieta, CA
- St. Joseph Hospital Center for Cancer Prevention and Treatment · Orange, CA
- University of California Irvine · Orange, CA
- UC Davis Comprehensive Cancer Center · Sacramento, CA
- UCSF Zuckerberg San Francisco General Hospital · San Francisco, CA
- Sansum Clinic · Santa Barbara, CA
- Kaiser Permanente Santa Clara Medical Center · Santa Clara, CA
- Providence Medical Foundation 1 · Santa Rosa, CA
- City of Hope South Pasadena · South Pasadena, CA
- City of Hope Upland · Upland, CA
- Kaiser Permanente Northern California · Vallejo, CA
- John Muir Health Clinical Research Center · Walnut Creek, CA
- Kaiser Permanente Walnut Creek Medical Center · Walnut Creek, CA
Colorado · 1
- Rocky Mountain Cancer Centers · Lone Tree, CO
Connecticut · 1
- Yale New Haven Hospital Yale Cancer Center · New Haven, CT
Delaware · 1
- ChristianaCare Helen F Graham Cancer Center and Research Institute · Newark, DE
District of Columbia · 2
- MedStar Georgetown University Hospital · Washington D.C., DC
- Washington DC VA Medical Center · Washington D.C., DC
Florida · 15
- Baptist Lynn Cancer Institute · Boca Raton, FL
- The Oncology Institute of Hope and Innovation 1 · Fort Lauderdale, FL
- Florida Cancer Specialists · Fort Myers, FL
- Univ of Florida · Gainesville, FL
- Memorial Regional Hospital · Hollywood, FL
- Baptist MD Anderson Cancer Center · Jacksonville, FL
- Mayo Clinic · Jacksonville, FL
- Baptist Health Miami Cancer Institute · Miami, FL
- Sylvester Comprehensive Cancer Center · Miami, FL
- AdventHealth Orlando · Orlando, FL
- Orlando Health Cancer Institute · Orlando, FL
- Memorial Cancer Institute · Pembroke Pines, FL
- Florida Cancer Specialists & Research Institute 1 · St. Petersburg, FL
- Moffitt Cancer Center · Tampa, FL
- Florida Cancer Specialists & Research Institute · West Palm Beach, FL
Georgia · 5
- Grady Health System Correll Pavilion · Atlanta, GA
- Piedmont Cancer Institute · Atlanta, GA
- Piedmont Healthcare · Atlanta, GA
- Winship Cancer Institute Emory University · Atlanta, GA
- City of Hope Cancer Center · Newnan, GA
Illinois · 5
- Rush University Medical Center Rush University Cancer Center Chicago · Chicago, IL
- University of Illinois at Chicago · Chicago, IL
- Cancer Care Specialists of Central Illinois · Decatur, IL
- Illinois CancerCare · Peoria, IL
- City of Hope Chicago · Zion, IL
Indiana · 2
- Fort Wayne Medical Oncology and Hematology · Fort Wayne, IN
- Investigative Clinical Research of Indiana, LLC · Noblesville, IN
Iowa · 1
- Accellacare of McFarland · Ames, IA
Kansas · 1
- University of Kansas Cancer Center · Fairway, KS
Maryland · 2
- University of Maryland · Baltimore, MD
- Maryland Oncology Hematology P A · Silver Spring, MD
Massachusetts · 3
- Beth Israel Deaconess Medical Center · Boston, MA
- Boston University Medical Center · Boston, MA
- Dana Farber Cancer Institute · Boston, MA
Michigan · 2
- University of Michigan Health System · Ann Arbor, MI
- Trinity Health St Joseph Mercy Ann Arbor · Ypsilanti, MI
Minnesota · 2
- University Of Minnesota · Minneapolis, MN
- Mayo Clinic Rochester · Rochester, MN
Missouri · 3
- Truman Medical Ctr West · Kansas City, MO
- Oncology Hematology Associates · Springfield, MO
- Washington University School Of Medicine · St Louis, MO
New Hampshire · 1
- Dartmouth Hitchcock Medical Center · Lebanon, NH
New Jersey · 3
- Morristown Medical Center · Morristown, NJ
- Rutgers Cancer Institute of New Jersey · New Brunswick, NJ
- Overlook Medical Center · Summit, NJ
New Mexico · 1
- University of New Mexico · Albuquerque, NM
New York · 7
- Hematology-Oncology Associates of CNY · East Syracuse, NY
- Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island · Mineola, NY
- Herbert Irving Comprehensive Cancer Center Columbia University Medical Center · New York, NY
- NYU Langone Health Laura and Isaac Perlmutter Cancer Center · New York, NY
- Ellis Hospital · Schenectady, NY
- New York Cancer and Blood Specialists · Shirley, NY
- Montefiore Medical Center · The Bronx, NY
North Carolina · 3
- Atrium Health · Charlotte, NC
- Regional Medical Oncology Center · Wilson, NC
- Atrium Health Wake Forest Baptist Comprehensive Cancer Center · Winston-Salem, NC
Ohio · 1
- Cincinnati Veterans Affairs Medical Center · Cincinnati, OH
Oregon · 2
- Oncology Associates of Oregon PC Willamette Valley Cancer Institute · Eugene, OR
- Oregon Health And Science University · Portland, OR
Pennsylvania · 3
- Jefferson Health Northeast · Philadelphia, PA
- Thomas Jefferson University Hospital · Philadelphia, PA
- McGlinn Cancer Institute Reading Hospital · West Reading, PA
South Carolina · 1
- Medical University of South Carolina · Charleston, SC
Tennessee · 5
- Tennessee Oncology - Chattanooga · Chattanooga, TN
- Tennessee Cancer Specialists · Knoxville, TN
- University of Tennessee · Knoxville, TN
- SCRI Oncology Partners · Nashville, TN
- Tennessee Oncology · Nashville, TN
Texas · 11
- Texas Oncology South · Austin, TX
- Parkland Health and Hospital System · Dallas, TX
- Texas Oncology DFW · Dallas, TX
- UT Southwestern Medical Center · Dallas, TX
- MD Anderson Cancer Center · Houston, TX
- Oncology Consultants Texas · Houston, TX
- Texas Oncology San Antonio Northeast · San Antonio, TX
- Community Clinical Trials · Spring, TX
- Texas Oncology - Northeast · Tyler, TX
- The University of Texas Health Science Center at Tyler · Tyler, TX
- Texas Oncology-Gulf Coast · Webster, TX
Utah · 1
- Huntsman Cancer Institute · Salt Lake City, UT
Virginia · 1
- Virginia Cancer Specialists · Fairfax, VA
Washington · 2
- Vista Oncology · Olympia, WA
- Summit Cancer Centers · Spokane, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.