A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
NCT06662786
This study is recruiting at 81 US sites in 31 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, oxaliplatin (mFOLFOX6) or 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, and irinotecan hydrochloride (FOLFIRI) versus cetuximab and mFOLFOX6 or FOLFIRI in adult participants with Kirsten rat sarcoma viral oncogene homolog (KRAS)/ Neuroblastoma RAS viral oncogene homolog (NRAS) and v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) wild…
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Colorectal Neoplasms
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Janssen Research & Development, LLC
- Last updated on ClinicalTrials.gov
- September 25, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Banner MD Anderson Cancer Center · Gilbert, AZ
Arkansas · 2
- St. Bernard's Medical Center · Jonesboro, AR
- Highlands Oncology Group · Springdale, AR
California · 7
- CBCC Global Research · Bakersfield, CA
- Los Angeles Cancer Network · Glendale, CA
- Cancer and Blood Specialty Clinic · Los Alamitos, CA
- USC Norris Comprehensive Cancer Center · Los Angeles, CA
- UCLA · Santa Monica, CA
- Providence Medical Foundation · Santa Rosa, CA
- Torrance Memorial Physicians Network · Torrance, CA
Colorado · 1
- Rocky Mountain Cancer Centers · Denver, CO
Connecticut · 1
- Yale University School Of Medicine · New Haven, CT
District of Columbia · 1
- Georgetown Univ Medical Center Lombardi Cancer Center · Washington D.C., DC
Florida · 4
- Florida Cancer Specialists South · Fort Myers, FL
- AdventHealth Medical Group Oncology and Hematology at Orlando · Orlando, FL
- Florida Cancer Specialists North Region · St. Petersburg, FL
- Florida Cancer Specialists East · West Palm Beach, FL
Georgia · 2
- Grady Memorial Hospital · Atlanta, GA
- Winship Cancer Institute Emory University · Atlanta, GA
Illinois · 2
- Illinois Cancer Specialists · Arlington Heights, IL
- Illinois CancerCare · Peoria, IL
Indiana · 1
- Fort Wayne Medical Oncology & Hematology · Fort Wayne, IN
Iowa · 2
- University of Iowa Hospital · Iowa City, IA
- Mission Cancer Blood · Waukee, IA
Kansas · 1
- Cancer Center of Kansas · Wichita, KS
Louisiana · 1
- Ochsner Clinic Foundation · New Orleans, LA
Maryland · 2
- MedStar Franklin Square Medical Center · Baltimore, MD
- Frederick Health Hospital - James M Stockman Cancer Institute · Frederick, MD
Michigan · 4
- University of Michigan · Ann Arbor, MI
- VA Ann Arbor Healthcare System · Ann Arbor, MI
- Henry Ford Hospital · Detroit, MI
- Start Midwest · Grand Rapids, MI
Mississippi · 1
- Hattiesburg Clinic · Hattiesburg, MS
Missouri · 1
- Washington University School Of Medicine · St Louis, MO
Nebraska · 1
- Nebraska Cancer Specialists Midwest Cancer Center · Omaha, NE
Nevada · 1
- Comprehensive Cancer Centers of Nevada · Las Vegas, NV
New Jersey · 2
- Astera Cancer Care · East Brunswick, NJ
- Rutgers Cancer Institute · New Brunswick, NJ
New Mexico · 1
- University of New Mexico Cancer Center · Albuquerque, NM
New York · 8
- Perlmutter Cancer Center at NYU Long Island · Mineola, NY
- Herbert Irving Comprehensive Cancer Center Columbia University Medical Center · New York, NY
- Mount Sinai · New York, NY
- Mount Sinai West · New York, NY
- NYU Langone Medical Center NYU Hematology Associates · New York, NY
- New York Cancer and Blood Specialists · Shirley, NY
- Montefiore Einstein Comprehensive Cancer Center · The Bronx, NY
- University of Buffalo Kaleida Health Cancer Care · Williamsville, NY
North Carolina · 1
- University of North Carolina at Chapel Hill · Chapel Hill, NC
Ohio · 11
- Gabrail Cancer Center · Canton, OH
- Cleveland Clinic Cancer Center Fairview Hospital Moll Pavilion · Cleveland, OH
- Taussig Cancer Insititute Cleveland Clinic · Cleveland, OH
- University Hospitals Cleveland Medical Center · Cleveland, OH
- Cleveland Clinic Cancer Center Independence Family Health Center · Independence, OH
- Cleveland Clinic Cancer Center Mansfield · Mansfield, OH
- Cleveland Clinic Cancer Center Hillcrest Hospital · Mayfield Heights, OH
- Cleveland Clinic Cancer Centers Sandusky · Sandusky, OH
- Cleveland Clinic Cancer Center Strongsville · Strongsville, OH
- Cleveland Clinic Cancer Center South Pointe Hospital · Warrensville Heights, OH
- Wooster Milltown Specialty and Surgery Center · Wooster, OH
Oregon · 2
- St Charles Medical Center · Bend, OR
- Oregon Health And Science University · Portland, OR
Pennsylvania · 3
- Fox Chase Cancer Center · Philadelphia, PA
- Thomas Jefferson University · Philadelphia, PA
- University Of Pittsburgh Medical Center UPMC Hillman Cancer Center · Pittsburgh, PA
Tennessee · 1
- SCRI Oncology Partners · Nashville, TN
Texas · 7
- Texas Oncology West Texas · Abilene, TX
- Texas Oncology DFW · Dallas, TX
- UT Southwestern · Dallas, TX
- MD Anderson Cancer Center · Houston, TX
- Baylor Scott and White Health 1 · Round Rock, TX
- Texas Oncology - San Antonio · San Antonio, TX
- Baylor Scott and White Health · Temple, TX
Virginia · 4
- Virginia Cancer Specialists · Arlington, VA
- Inova Schar Cancer Institute Dept of Fairfax Hospital · Fairfax, VA
- Richmond VA Medical Center · Richmond, VA
- VCU Massey Comprehensive Cancer Center · Richmond, VA
Washington · 4
- Swedish Cancer Institute Edmonds · Edmonds, WA
- Swedish Cancer Institute Issaquah · Issaquah, WA
- Fred Hutchinson Cancer Research Center · Seattle, WA
- Swedish Cancer Institute · Seattle, WA
Wisconsin · 1
- William S. Middleton Memorial VA · Madison, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.