Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer
NCT06661720
This study is recruiting at 402 US sites in 42 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of adding tivozanib to standard therapy pembrolizumab versus pembrolizumab alone for the treatment of patients with high-risk renal cell carcinoma (RCC). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Tivozanib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals tumor cells to multiply. This helps stop the spread of tumor cells.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Clear Cell Renal Cell Carcinoma
- Renal Cell Carcinoma (RCC)
- Stage II Renal Pelvis Cancer AJCC v8
- Stage III Renal Pelvis Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Alliance for Clinical Trials in Oncology
- Last updated on ClinicalTrials.gov
- September 2, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
Arkansas · 2
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro · Jonesboro, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 26
- Sutter Auburn Faith Hospital · Auburn, CA
- Tower Cancer Research Foundation · Beverly Hills, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- City of Hope at Irvine Lennar · Irvine, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- City of Hope Antelope Valley · Lancaster, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Memorial Medical Center · Modesto, CA
- USC Norris Oncology/Hematology-Newport Beach · Newport Beach, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Palo Alto Medical Foundation Health Care · Palo Alto, CA
- Sutter Roseville Medical Center · Roseville, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- UC San Diego Medical Center - Hillcrest · San Diego, CA
- California Pacific Medical Center-Pacific Campus · San Francisco, CA
- Mills Health Center · San Mateo, CA
- Palo Alto Medical Foundation-Santa Cruz · Santa Cruz, CA
- Palo Alto Medical Foundation-Sunnyvale · Sunnyvale, CA
- City of Hope South Bay · Torrance, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- City of Hope Upland · Upland, CA
- Sutter Solano Medical Center/Cancer Center · Vallejo, CA
Colorado · 10
- UCHealth University of Colorado Hospital · Aurora, CO
- Memorial Hospital North · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- UCHealth - Cherry Creek · Denver, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- UCHealth Highlands Ranch Hospital · Highlands Ranch, CO
- UCHealth Lone Tree Health Center · Lone Tree, CO
- Medical Center of the Rockies · Loveland, CO
Connecticut · 18
- Hartford HealthCare - Avon · Avon, CT
- Hartford HealthCare - Saint Vincent's Medical Center · Bridgeport, CT
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Hartford Healthcare - Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Hartford Hospital · Hartford, CT
- Hartford HealthCare - Manchester · Manchester, CT
- Midstate Medical Center · Meriden, CT
- The Hospital of Central Connecticut · New Britain, CT
- Yale University · New Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Stamford Hospital/Bennett Cancer Center · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 4
- Beebe South Coastal Health Campus · Millville, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
District of Columbia · 1
- MedStar Washington Hospital Center · Washington D.C., DC
Florida · 2
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- Miami Cancer Institute · Miami, FL
Georgia · 5
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
- Emory Johns Creek Hospital · Johns Creek, GA
Idaho · 7
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 56
- Advocate Outpatient Center - Aurora · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Northwestern University · Chicago, IL
- Rush MD Anderson Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Elmhurst Memorial Hospital · Elmhurst, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Trinity Medical Center · Moline, IL
- Edward Hospital/Cancer Center · Naperville, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Advocate Outpatient Center - Oak Lawn · Oak Lawn, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate High Tech Medical Park · Palos Heights, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Edward Hospital/Cancer Center?Plainfield · Plainfield, IL
- Illinois CancerCare-Princeton · Princeton, IL
- UW Health Carbone Cancer Center Rockford · Rockford, IL
- Memorial Hospital East · Shiloh, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 4
- IU Health West Hospital · Avon, IN
- IU Health North Hospital · Carmel, IN
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
- Sidney and Lois Eskenazi Hospital · Indianapolis, IN
Iowa · 8
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- University of Iowa Healthcare Cancer Services Quad Cities · Bettendorf, IA
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
Kentucky · 4
- University of Kentucky/Markey Cancer Center · Lexington, KY
- Baptist Health Louisville · Louisville, KY
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Louisiana · 1
- Ochsner Medical Center Jefferson · New Orleans, LA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.