A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
NCT06647498
This study is recruiting at 12 US sites in 12 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer disease in individuals with AD-causing mutations. This study will also investigate the effects of remternetug on biomarkers (measures of the disease including brain scans, blood and spinal fluid tests), examine safety data to identify any potential benefits or risks, and examine how well participants can tolerate remternetug.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Alzheimers Disease
- Dementia
- Alzheimers Disease, Familial
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2/3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Sponsor
- Washington University School of Medicine
- Last updated on ClinicalTrials.gov
- July 27, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama in Birmingham · Birmingham, AL
California · 1
- University of California San Diego Medical Center · La Jolla, CA
Connecticut · 1
- Yale University School of Medicine · New Haven, CT
Georgia · 1
- Emory University · Atlanta, GA
Illinois · 1
- Advocate Lutheran General Hospital · Park Ridge, IL
Indiana · 1
- Indiana University School of Medicine · Indianapolis, IN
Missouri · 1
- Washington University in St. Louis · St Louis, MO
New York · 1
- New York University Medical Center · New York, NY
Pennsylvania · 1
- University of Pittsburgh · Pittsburgh, PA
Rhode Island · 1
- Butler Hospital · Providence, RI
Texas · 1
- Kerwin Research and Memory Center · Dallas, TX
Washington · 1
- University of Washington · Seattle, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.